ArticleJournal of bone and mineral metabolism2020
Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus.
Article in Journal of bone and mineral metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of GLP-1 Receptor Agonists on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus: A 52-Week Clinical Study.BioMed research international · 2021Trial
- Impact of the visceral adipose tissue on bone quality in patients with untreated mild-to-severe obstructive sleep apnea.Journal of sleep research · 2025Article
- Use of noninvasive imaging to identify causes of skeletal fragility in adults with diabetes: a review.JBMR plus · 2024Review
- Areal bone mineral density, trabecular bone score and 3D-DXA analysis of proximal femur in psoriatic disease.Frontiers in medicine · 2024Article
- High physical activity in persons with psoriatic arthritis is associated with reduced visceral fat mass and percentage body fat: the Trøndelag Health study.Rheumatology international · 2023Article
- Factors associated with trabecular bone score in postmenopausal women with type 2 diabetes and normal bone mineral density.World journal of diabetes · 2022Article
- Sodium-glucose cotransporter 2 inhibitors do not increase the risk of fractures in real-world clinical practice in Korea: A national observational cohort study.Journal of diabetes investigation · 2022Observational
- Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review.Journal of clinical medicine · 2022Review
- Circulating SIRT1 and Sclerostin Correlates with Bone Status in Young Women with Different Degrees of Adiposity.Nutrients · 2022Article
- Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2022Article
- Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus.Archives of endocrinology and metabolism · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiabetes has been proposed as a risk factor for increased skeletal fragility. Visceral fat is known to yield adverse effects on bone metabolism in people with diabetes. We investigated the relationship between the change in visceral fat mass over time and TBS or BMD. MATERIALS AND
methodsThis retrospective study enrolled 690 (male: 367; female: 323) subjects with type 2 diabetes mellitus. Visceral fat mass, lumbar and femoral neck BMD, and lumbar spine TBS were measured via dual-energy X-ray absorptiometry (DXA), including the follow-up data within a 3-year period.
resultsTBS significantly increased as visceral fat mass decreased in both sexes (p < 0.001), whereas lumbar BMD and femoral neck BMD showed meaningful changes only in men. The multiple regression model with adjustment for age, weight, creatinine level, lipid profile, HbA1C, and status of osteoporosis medication use revealed that TBS and femoral neck BMD were correlated with visceral fat mass. However, regarding longitudinal changes, only the change in visceral fat mass had a significant relationship with TBS (males: β = - 0.298, p < 0.001; females: β = - 0.216, p < 0.001).
conclusionsThe results of this study may suggest the beneficial effect of controlling visceral fat mass on bone health in type 2 diabetes patients. Besides, DXA-derived TBS could be a useful diagnostic tool for evaluating the bone changes according to metabolic changes in type 2 diabetes, which are not entirely achieved with BMD.
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