Evidence map›Paper›PMID 32399633›Full record

ArticlePsychopharmacology2020

Role of the stress response and the endocannabinoid system in Δ

Marieka V DeVuono, Olivia La Caprara, Megan T Sullivan, Alexandra Bath, Gavin N Petrie, Cheryl L Limebeer, Erin M Rock, Matthew N Hill, Linda A Parker

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Endocannabinoid signaling in stress, nausea, and vomiting.Neurogastroenterology and motility · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Cannabidiol Interferes with Establishment of ΔCannabis and cannabinoid research · 2022
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marieka V DeVuonoDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Olivia La CapraraDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Megan T SullivanDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Alexandra BathDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Gavin N PetrieDepartments of Cell Biology and, Anatomy and Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Cheryl L LimebeerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Erin M RockDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Matthew N HillDepartments of Cell Biology and, Anatomy and Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Linda A ParkerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. parkerl@uoguelph.ca.
University of Guelph · CAUniversity of Calgary · CA

Funding

Canadian Institutes of Health Research 388239Natural Sciences and Engineering Research Council of Canada 03629
6 · The paper itself

Abstract

rationaleDysregulation of the endocannabinoid (eCB) system by high doses of Δ OBJECTIVES AND

methodsUsing the conditioned gaping model of nausea, we aimed to determine if pre-treatments that interfere with stress, or an anti-emetic drug, interfere with THC-induced nausea in male rats. The corticotropin-releasing hormone (CRH) antagonist, antalarmin, was given to inhibit the HPA axis during conditioning. Since eCBs inhibit stress, MJN110 (which elevates 2-arachidonylglycerol (2-AG)) and URB597 (which elevates anandamide (AEA)) were also tested. Propranolol (β-adrenergic antagonist) and WAY-100635 (5-HT

resultsAntalarmin (10 and 20 mg/kg), MJN110 (10 mg/kg), URB597 (0.3 mg/kg), propranolol (2.5 and 5 mg/kg), WAY-100635 (0.5 mg/kg), and chlordiazepoxide (5 mg/kg) interfered with THC-induced conditioned gaping, but the anti-emetic ondansetron (0.1 and 0.01 mg/kg) did not. THC produced significantly higher CORT levels at 10 mg/kg than at 0.0 and 0.5 mg/kg THC.

conclusionsTreatments that interfere with the stress response also inhibit THC-induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and CHS, is a result of a dysregulated stress response.

Indexed as

AnimalsAntiemeticsCannabinoid Receptor AgonistsDronabinolEndocannabinoidsHypothalamo-Hypophyseal SystemMaleNauseaPituitary-Adrenal SystemRatsRats, Sprague-DawleyAntiemeticsCannabinoid Receptor AgonistsDronabinolEndocannabinoidsCannabinoid hyperemesis syndrome (CHS)Conditioned gapingCorticosteroneEndocannabinoidsHypothalamic-pituitary-adrenal (HPA) axisNauseaΔ9-tetrahydrocannabinol (THC)

Identifiers

PMID32399633
OpenAlexW3025449129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.