Evidence map›Paper›PMID 32399622›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

First-in-human evaluation of [

Min-Jeong Kim, Jae-Hoon Lee, Fernanda Juarez Anaya, Jinsoo Hong, William Miller, Sanjay Telu, Prachi Singh, Michelle Y Cortes, Katharine Henry, George L Tye and 7 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03324646 (Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03324646 completednot on this map

Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)

TypeobservationalSponsorNational Institute of Mental Health (NIMH)Ran2017 to 2024Enrolled52ConditionsNormal PhysiologyArms[11C]PS13
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  6. Article
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  10. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  11. Review
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  17. Review
  18. Review
  19. Whole-Body PET Imaging in Humans Shows ThatJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. [European journal of nuclear medicine and molecular imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Min-Jeong KimMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA. min-jeong.kim@nih.gov.ORCID 0000-0002-0998-5972
Jae-Hoon LeeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Fernanda Juarez AnayaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Jinsoo HongMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
William MillerMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Sanjay TeluMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Prachi SinghMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Michelle Y CortesMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Katharine HenryMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
George L TyeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Michael P FranklandMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Jose A Montero SantamariaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Masahiro FujitaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.
National Institutes of Health · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795
6 · The paper itself

Abstract

purposeThis study assessed whether the newly developed PET radioligand [

methodsBrain test-retest scans with concurrent arterial blood samples were obtained in 10 healthy individuals. The one- and unconstrained two-tissue compartment models, as well as the Logan graphical analysis were compared, and test-retest reliability and time-stability of total distribution volume (V

resultsIn the brain, [

conclusionsThese results from the first-in-human evaluation of the ability of [ CLINICAL

trial registrationNCT03324646 at https://clinicaltrials.gov/ . Registered October 30, 2017. Retrospectively registered.

Indexed as

BrainPositron-Emission TomographyAnimalsCyclooxygenase 1HumansRadiopharmaceuticalsReproducibility of ResultsCyclooxygenase 1RadiopharmaceuticalsCyclooxygenase-1InflammationNeuroimagingPositron emission tomographyTest-retest reliability

Identifiers

PMID32399622
PMCPMC8261645
OpenAlexW3025691939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.