Evidence map›Paper›PMID 32399465›Full record

ArticleGastrointestinal tumors2020

Changing Patterns of Hepatocellular Carcinoma after Treatment with Direct Antiviral Agents.

Mohammed El Fayoumie, Mahmoud Abdelhady, Ahmed Gawish, Usama Hantour, Ismail Abdelkhaleek, Mohamed Abdelraheem, Alaa Alsawak, Ahmed Alwassief, Ashraf Elbahrawy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastrointestinal tumors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mohammed El FayoumieDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Mahmoud AbdelhadyDepartment of Surgery, Al-Azhar University, Cairo, Egypt.
Ahmed GawishDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Usama HantourDepartment of Tropical Medicine, Al-Azhar University, Cairo, Egypt.
Ismail AbdelkhaleekDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed AbdelraheemDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Alaa AlsawakDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed AlwassiefDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Ashraf ElbahrawyDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.
Al-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe impact of direct antiviral agents (DAAs) on the development of hepatocellular carcinoma (HCC) is controversial. One important aspect of this controversy is the changing pattern of HCC.

objectiveIn this study, we attempted to assess the changes in the pattern of HCC after treatment with DAAs.

methodsA total of 51 HCC patients after DAA treatment and 54 HCC patients without DAA treatment were included. The diagnosis of HCC was based on typical dynamic CT and/or MRI criteria in both groups. Liver status was assessed by means of the fibrosis 4 index (Fib-4), Child-Pugh classification, and model for end-stage liver disease (MELD). HCC infiltrative pattern, portal vein thrombosis (PVT), local and distant metastases, and α-fetoprotein (AFP) level were compared in the 2 groups. The staging of HCC and treatment decisions were made in both groups following the Milan criteria, Barcelona Clinic Liver Cancer staging, tumor-node-metastasis staging, and Cancer of the Liver Italian Program categorization.

resultsThe mean age of the HCC patients after DAA treatment (59.1± 7.4 years) was older than that of the HCC patients without DAA treatment. There was no significant difference between groups regarding sex distribution. The mean Fib-4 score (4.84 ± 3.53) was significantly lower in HCC patients after DAA treatment than in those without DAA treatment. The frequency of the infiltrative HCC pattern, PVT, and regional lymph node metastasis was significantly higher in HCC patients after DAA treatment than in those without DAA treatment (

conclusionThe changing HCC pattern after DAA treatment may suggest the need for new HCC staging and treatment protocols.

Indexed as

Direct antiviral agentsHCC patternHepatitis C virusHepatocellular carcinoma

Identifiers

PMID32399465
PMCPMC7206583
OpenAlexW3000532092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.