ReviewCureus2020
The Pathophysiology of Type 2 Diabetes Mellitus in Non-obese Individuals: An Overview of the Current Understanding.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Incidence and temporal trends in type 2 diabetes by weight status: A systematic review and meta-analysis of prospective cohort studies.Journal of global health · 2023Pooled it
- A Combined Probiotic-International journal of molecular sciences · 2026Article
- Evaluation of a diabetes decentralization program in rural Madagascar using the RE-AIM framework.PLOS global public health · 2026Article
- Lipidomic Signatures of Insulin Resistance Identified From Hyperinsulinemic-Euglycemic Clamp Studies in Asian Men.Diabetes · 2025Article
- Comparison of clinical characteristics and dietary intakes according to phenotypes of type 2 diabetes mellitus in South Korea: a cross-sectional study.Korean journal of community nutrition · 2025Article
- Identification of genetic loci enriched in obese or lean T2D cases in the Korean population.Genes & genomics · 2025Article
- Heterogeneity of type 2 diabetes in rural India.Frontiers in endocrinology · 2025Article
- Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus.Chonnam medical journal · 2025Review
- Retrospective Evaluation of the Impact of a Multidisciplinary One-Year Online Lifestyle Intervention on Type 2 Diabetes Remission in Nonobese Indian Patients.Journal of diabetes research · 2025Article
- Reverse epidemiology of obesity paradox: Fact or fiction?Physiological reports · 2024Review
- Prevalence of and factors associated with pre-diabetes among adolescents in Eastern Sudan: a community-based cross-sectional study.BMJ open · 2024Article
- Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster.Scientific reports · 2024Article
- The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population.BMC endocrine disorders · 2024Article
- Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes.Nutrients · 2024Review
- Socioeconomic gradient of lean diabetes in India: Evidence from National Family Health Survey, 2019-21.PLOS global public health · 2024Article
- Triglyceride to high-density lipoprotein cholesterol ratio is associated with diabetes incidence in non-obese individuals with normoglycemia: a retrospective cohort study based on individuals from East Asia.Frontiers in endocrinology · 2024Article
- Periodontitis is associated with insulin resistance in adults living with diabetes mellitus in Uganda: a cross- sectional study.BMC research notes · 2023Article
- Racial/Ethnic, Biomedical, and Sociodemographic Risk Factors for COVID-19 Positivity and Hospitalization in the San Francisco Bay Area.Journal of racial and ethnic health disparities · 2023Article
- Association between serum leptin concentrations and homeostasis model assessment-insulin resistance of 2.5 and higher in normal weight Japanese women.Scientific reports · 2023Article
- Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pandemic of type 2 diabetes mellitus (T2DM) has been largely attributed to the increasing prevalence of worldwide obesity at a geometric rate. However, the number of non-obese patients with T2DM is also on the rise, and it is as high as 60-80% in some Asian countries. These non-obese individuals have certain peculiarities and have a higher mortality rate compared with obese individuals. The pathophysiology of T2DM in non-obese individuals remains poorly understood, and this has an impact on defining its management. This review discusses the current understanding of the pathophysiology of T2DM in non-obese individuals. The definition of T2DM in non-obese individuals remains controversial because of the limited clinical measurements, and the current definition of obesity using body mass index (BMI) is not very helpful as these individuals have BMIs of <25K g/m3, which is considered normal. Many authors have argued that the so-called non-obese people are actually metabolically obese; however, in terms of the measurements clinically available, they are non-obese. The simplistic understanding of the mechanism of the pathophysiology sees it in terms of the balance between insulin secretion and insulin resistance. The pathogenesis of insulin resistance in a lean patient has been proven to be the same as what is seen in an obese individual, but most studies confirm more severe functional insulin secretory defects in lean individuals compared to the obese phenotype. The mechanism underlying this form of T2DM is still poorly defined, and more research is required to understand the mechanism of sarcopenic obesity, which some studies have revealed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.