Evidence map›Paper›PMID 32399287›Full record

ArticleJournal of obesity2020

Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity.

Bingjie Zhou, Reiko Ichikawa, Laurence D Parnell, Sabrina E Noel, Xiyuan Zhang, Shilpa N Bhupathiraju, Caren E Smith, Katherine L Tucker, Jose M Ordovas, Chao-Qiang Lai

Open access · goldAbstract read
In one paragraph

Article in Journal of obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population.Metabolomics : Official journal of the Metabolomic Society · 2021
    Article
  10. Observational
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Bingjie Zhou *Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Reiko Ichikawa *Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Laurence D ParnellUSDA Agricultural Research Service, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Sabrina E NoelDepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
Xiyuan ZhangDepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
Shilpa N BhupathirajuChanning Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Caren E SmithNutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID 0000-0002-9511-1103
Katherine L TuckerDepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
Jose M OrdovasNutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID 0000-0002-7581-5680
Chao-Qiang LaiUSDA Agricultural Research Service, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID 0000-0003-1107-8375
Tufts University · USUniversity of Massachusetts Lowell · USBrigham and Women's Hospital · USMadrid Institute for Advanced Studies · ES

Funding

STATISTICSP50HL105185 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2010 to 2015
$10.4M
Center for Research/Nutrition &Health among the ElderlyP01AG023394 · NIA · TUFTS UNIVERSITY BOSTON · PI TUCKER, KATHERINE L · 2003 to 2007
$8.1M
Dietary Quality, Cognitive Decline and Brain Health in Puerto Rican AdultsR01AG055948 · NIA · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2017 to 2021
$4.2M
Metabolomics and Type 2 Diabetes in a Cohort of Older Puerto RicansK01DK107804 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI BHUPATHIRAJU, SHILPA NANDANA · 2016 to 2019
$594k
Diet and Health Behavior Change to Improve Bone HealthK01AR067894 · NIAMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI NOEL, SABRINA · 2015 to 2019
$504k
NHLBI NIH HHS P50 HL105185NIAMS NIH HHS K01 AR067894NIA NIH HHS P01 AG023394NIA NIH HHS R01 AG055948NIDDK NIH HHS K01 DK107804
6 · The paper itself

Abstract

Background: Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood. Objective: Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms. Design: We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45-75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors. Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk. Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity. Results: SSB intake was correlated with BMI ( Conclusions: We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk. The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.

Indexed as

AcyltransferasesAgedEnergy IntakeFemaleHumansMaleMetabolomicsMiddle AgedObesitySugar-Sweetened BeveragesAcyltransferasesphosphatidylethanolamine N-acyltransferase

Identifiers

PMID32399287
PMCPMC7211252
OpenAlexW3023435467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.