Evidence map›Paper›PMID 32399278›Full record

ArticleJournal of gastrointestinal oncology2020

Survival benefits of palliative gastrectomy in stage IV gastric cancer: a propensity score matched analysis.

Wanren Peng, Tai Ma, Hui Xu, Zhijun Wu, Changhao Wu, Guoping Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Clinical impact of gastrectomy in surgically proven stage IV gastric cancers: retrospective analysis from Korean multicenter dataset (PASS-META).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  4. PALLIATIVE GASTRECTOMY VERSUS GASTRIC BYPASS FOR SYMPTOMATIC CLINICAL STAGE IV GASTRIC CANCER: A PROPENSITY SCORE MATCHING ANALYSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Wanren PengDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Tai MaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Hui XuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Zhijun WuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Changhao WuFaculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.
Guoping SunDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CNUniversity of Surrey · GB

Funding

Nox Enzymes in Aging Bladder DysfunctionR01AG049321 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI BARBE, MARY F · 2016 to 2020
$1.7M
Biotechnology and Biological Sciences Research Council BB/G015554/1NIA NIH HHS R01 AG049321
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the effect of palliative gastrectomy on survival in stage IV gastric cancer.

methodsPatients diagnosed with stage IV gastric cancer between 2010 and 2016 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Survival curves were estimated by the Kaplan-Meier method before and after propensity score matching (PSM). Univariate and multivariate Cox analyses were performed to evaluate risk factors for survival in patients who underwent palliative gastrectomy.

resultsWe examined 6,529 patients with stage IV gastric cancer, of which 625 underwent palliative gastrectomy. Using a 1:2 PSM, the 625 patients were matched with 1,250 patients from the no gastrectomy group. The overall survival was higher in the gastrectomy group before [hazard ratio (HR) =0.57, 95% confidence interval (CI): 0.53-0.62, P<0.0001] and after PSM (HR =0.51, 95% CI: 0.46-0.57, P<0.0001). Multivariate Cox analysis confirmed the survival benefits of palliative gastrectomy and chemotherapy. Older age, over-lapping lesions, non-adenocarcinomas, higher tumor grade, and lung metastasis significantly increased the risk of mortality. In the gastrectomy group, patients aged ≥80 years, diagnosed with grades 3/4 non-adenocarcinomas, or with lung metastasis showed poorer prognosis. However, chemotherapy could improve the survival of these patients.

conclusionsPalliative gastrectomy provides survival benefits to stage IV gastric cancer patients. However, age, tumor grade, tumor histology, and lung metastasis status should be considered while making a decision regarding gastrectomy. Chemotherapy should also be recommended for these patients.

Indexed as

Gastric cancerpalliative gastrectomysurvival analysis

Identifiers

PMID32399278
PMCPMC7212110
OpenAlexW3011316439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.