Evidence map›Paper›PMID 32399273›Full record

ArticleJournal of gastrointestinal oncology2020

Surgical resection of metastatic pancreatic cancer: is it worth it?-a 15-year experience at a single Chinese center.

Jiangning Gu, Zhiwei Xu, Yang Ma, Hao Chen, Di Wang, Xiaxing Deng, Dongfeng Cheng, Junjie Xie, Jiabin Jin, Xi Zhan and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Jiangning GuDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Zhiwei XuDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Yang MaDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Hao ChenDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Di WangScientific Research Management Office Eye and Ent Hospital, Fudan University, Shanghai 200031, China.
Xiaxing DengDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Dongfeng ChengDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Junjie XieDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Jiabin JinDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Xi ZhanDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Yuan ShiDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Yusheng ShiDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Youwei ZhuDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Baiyong ShenDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Chenghong PengDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200020, China.
Shanghai Jiao Tong University · CNRuijin Hospital · CNEye & ENT Hospital of Fudan University · CNFirst Affiliated Hospital of Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe significance of surgical resection in the treatment of metastatic pancreatic ductal adenocarcinoma (PDAC) is currently unclear. This study aimed to summarize and clarify the experience of surgical treatment of M1 PDAC in our center and evaluate whether it may offer benefits to some metastatic PDAC patients.

methodsWe analyzed the data of the patients with M1 PDAC who underwent synchronous tumor resection between 2003 and 2014 at Ruijin Hospital. Simultaneously, clinical data for M1 PDAC patients who underwent palliative bypass or exploratory laparotomy only was also collected during the same period as control. Every patient was followed up at least 3 years after hospitalization. The follow-up endpoint was December 31, 2017.

resultsA total of 36 patients underwent synchronous tumor resection; of them, 7 received postoperative adjuvant chemotherapy. Their 1-, 2-, and 3-year survival rates were 27.3%, 21.2%, and 7.1%, respectively, and the overall survival was 7.9 months. The overall survival of the palliative bypass and exploratory laparotomy groups was only 4 and 3.7 months, respectively (P<0.05).

conclusionsIt is unclear whether synchronous tumor resection can benefit M1 PDAC patients due to tumor heterogeneity and differences in tumor burden. However, our current experience indicated that synchronous tumor resection can be safely performed and might be appropriate for some highly selected patients due to the relatively longer survival time. Combined (neo)adjuvant chemotherapy would further prolong overall survival in these patients.

Indexed as

metastasisPancreatic adenocarcinomaretrospective studysurgical resection

Identifiers

PMID32399273
PMCPMC7212107
OpenAlexW3018961365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.