Evidence map›Paper›PMID 32399213›Full record

ArticleClinical & translational immunology2020

Dynamics of peripheral immune cells and their HLA-G and receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.

Sheng Zhang, Jun Gan, Bao-Guo Chen, Dan Zheng, Jian-Gang Zhang, Rong-Hai Lin, Yi-Ping Zhou, Wei-Ying Yang, Aifen Lin, Wei-Hua Yan

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Induction of pulmonary HLA-G expression by SARS-CoV-2 infection.Cellular and molecular life sciences : CMLS · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Hallmarks of Severe COVID-19 Pathogenesis:Frontiers in immunology · 2022
    Review
  11. Review
  12. Role of HLA-G in Viral Infections.Frontiers in immunology · 2022
    Review
  13. Mesenchymal stem cell transfusion: Possible beneficial effects in COVID-19 patients.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2021
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Potential role of interferons in treating COVID-19 patients.International immunopharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sheng ZhangDepartment of Intensive Care Unit TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Jun GanMedical Research Center TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Bao-Guo ChenMedical Research Center TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Dan ZhengDepartment of Intensive Care Unit TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Jian-Gang ZhangBiological Resource Center TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Rong-Hai LinDepartment of Intensive Care Unit TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Yi-Ping ZhouDepartment of Intensive Care Unit TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Wei-Ying YangDepartment of Intensive Care Unit TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Aifen LinBiological Resource Center TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.
Wei-Hua YanMedical Research Center TaiZhou Hospital of Zhejiang Province Wenzhou Medical University LinHai Zhejiang China.ORCID https://orcid.org/0000-0003-1774-7699
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHost immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen-G (HLA-G) and its receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.

methodsClinical data of the patient were collected from medical records. The expressions of HLA-G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry.

resultsFrom critical COVID-19 to the convalescent stage, early lymphopenia was improved (median: 0.6 × 10

conclusionOur findings provide valuable information on the dynamics of early peripheral immunological responses in SARS-CoV-2 infection. CD4

Indexed as

COVID‐19HLA‐Gperipheral immune cellsSARS‐CoV‐2

Identifiers

PMID32399213
PMCPMC7211507
OpenAlexW3020882634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.