Evidence map›Paper›PMID 32399174›Full record

ArticleMelanoma management2020

Durability of response in metastatic melanoma patients after combined treatment with radiation therapy and ipilimumab.

Quaovi H Sodji, Paulina M Gutkin, Susan M Swetter, Sunil A Reddy, Susan M Hiniker, Susan J Knox

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Melanoma management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Quaovi H SodjiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-9469-1388
Paulina M GutkinDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Susan M SwetterDepartment of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sunil A ReddyDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Susan M HinikerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Susan J KnoxDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USStanford Cancer InstituteVA Palo Alto Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe previously reported a prospective trial evaluating the safety and efficacy of combining ipilimumab and radiation therapy in patients with metastatic melanoma. Herein, we provide a long-term update on patients with complete response (CR) or partial response (PR). PATIENTS &

methodsWe continued to follow these patients with serial imaging including computed tomography, PET or MRI.

resultsTwo of the three patients with CR are still alive and without evidence of melanoma but with chronic treatment-induced hypophysitis. The third patient died of hepatocellular carcinoma, but with no evidence of melanoma. Among the three patients with PR, two achieved CR after pembrolizumab monotherapy.

conclusionThis long-term follow up reveals the striking durability of the CRs, which appears to correlate with a grade 2-3 hypophysitis.

Indexed as

hypophysitisimmunotherapymelanomaradiation therapy

Identifiers

PMID32399174
PMCPMC7212514
OpenAlexW3006355817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.