ArticleBehavioural neurology2020
Small Fiber Neuropathy: Clinicopathological Correlations.
Article in Behavioural neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A structured list of laboratory tests for screening the possible causes of small fiber neuropathy in clinical practice.Frontiers in neurology · 2025Review
- Assessment of small fiber neuropathy and distal sensory neuropathy in female patients with fibromyalgia.The Korean journal of internal medicine · 2024Article
- Antioxidant Effect in Diabetic Peripheral Neuropathy in Rat Model: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Age-dependent small fiber neuropathy: Mechanistic insights from animal models.Experimental neurology · 2024Review
- Neurological dysfunction screening in a cohort of adolescents with type 1 diabetes: a six-year follow-up.Frontiers in medicine · 2024Article
- Case Report: Angiostrongylus cantonensis Infection Presenting as Small Fiber Neuropathy.The American journal of tropical medicine and hygiene · 2022Article
- Neuropathic Low Back Pain and Burnout among Hungarian Workers.International journal of environmental research and public health · 2021Article
- Advances in imaging technologies for the assessment of peripheral neuropathies in rheumatoid arthritis.Rheumatology international · 2021Review
- Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria.Frontiers in neurology · 2021Review
- A Systematic Review of the Diagnostic Methods of Small Fiber Neuropathies in Rehabilitation.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small fiber neuropathy develops due to the selective damage of the thin fibers of peripheral nerves. Many common diseases can cause this condition, including diabetes, infections, autoimmune and endocrine disorders, but it can occur due to genetic alterations, as well. Eighty-five skin biopsy-proven small-fiber neuropathy cases were analyzed. Forty-one (48%) cases were idiopathic; among secondary types, hypothyreosis (9.4%), diabetes mellitus (7%), cryoglobulinemia (7%), monoclonal gammopathy with unproved significance (4.7%), Sjögren's disease (3%), and paraneoplastic neuropathy (3%) were the most common causes. Two-thirds (68%) of the patients were female, and the secondary type started 8 years later than the idiopathic one. In a vast majority of the cases (85%), the distribution followed a length-dependent pattern. Intraepidermal fiber density was comparable in idiopathic and secondary forms. Of note, we found significantly more severe pathology in men and in diabetes. Weak correlation was found between patient-reported measures and pathology, as well as with neuropathic pain-related scores. Our study confirmed the significance of small fiber damage-caused neuropathic symptoms in many clinical conditions, the gender differences in clinical settings, and pathological alterations, as well as the presence of severe small fiber pathology in diabetes mellitus, one of the most common causes of peripheral neuropathy.
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