Evidence map›Paper›PMID 32398967›Full record

ArticleCancer cell international2020

Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation.

Qi Chen, Qiuping Yin, Yemeng Mao, Zheyu Zhang, Siqi Wu, Zhang Cheng, Xinan Chen, Hanren Xu, Shengming Jin, Haowen Jiang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. MiR-147: Functions and Implications in Inflammation and Diseases.MicroRNA (Shariqah, United Arab Emirates) · 2021
    Review
  17. Circular RNAs and Bladder Cancer.OncoTargets and therapy · 2020
    Review
  18. Article
  19. The mStem cells international · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Qi Chen *1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Qiuping Yin *1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Yemeng Mao *3Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zheyu Zhang1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Siqi Wu1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Zhang Cheng1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Xinan Chen1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Hanren Xu4Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shengming Jin5Shanghai Cancer Center, Fudan University, Shanghai, China.
Haowen Jiang1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Chen Yang1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6011-4067
Fudan University · CNFudan University Shanghai Cancer Center · CNShanghai Mental Health Center · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) play an essential role in the regulation of gene expression. However, the underlying mechanisms remain unknown. This study aimed to evaluate the role of hsa_circ_0068307 in bladder cancer (BCa).

methodsRt-qPCR was used to detect hsa_circ_0068307 expression in BCa cell lines. The CCK8, colony formation, and Transwell assays were used to evaluate the effect of hsa_circ_0068307 on BCa cell migration and proliferation. Bioinformatics and luciferase reporter experiments were used to study the regulatory mechanism. Nude mouse xenografts were generated to examine the effect of hsa_circ_0068307 on tumor growth.

resultsThe results showed that hsa_circ_0068307 was upregulated in BCa cell lines. Downregulation of hsa_circ_0068307 suppressed cell migration and proliferation in T24 and UMUC3 cells. Hsa_circ_0068307 silencing suppressed cancer stem cell differentiation by upregulating miR-147 expression. Upregulation of miR-147 suppressed c-Myc expression, which is involved in cancer stem cell differentiation. Luciferase reporter assays confirmed that hsa_circ_0068307 upregulated c-Myc expression by targeting miR-147. In vivo studies showed that hsa_circ_0068307 knockdown suppressed T24 tumor growth.

conclusionsThese data indicate that downregulation of hsa_circ_0068307 reversed the stem cell-like properties of human bladder cancer through the regulation of the miR-147/c-Myc axis.

Indexed as

Bladder cancerCancer stem cellc-MycHsa_circ_0068307miR-147

Identifiers

PMID32398967
PMCPMC7204228
OpenAlexW3021282585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.