Evidence map›Paper›PMID 32398946›Full record

ArticleSarcoma2020

Long-Term Follow-up of a Randomized Study of Oral Etoposide versus

Alessandra Longhi, Marilena Cesari, Massimo Serra, Erminia Mariani

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Sarcoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05726383 (MISTOSUS), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05726383 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

MISTOSUS: Iscador® P (Mistletoe) Immunotherapy To Improve Event Free Survival In Patients With Relapsed Resectable Osteosarcoma

TypeinterventionalSponsorHackensack Meridian HealthRan2024 to 2027Enrolled32ConditionsOsteogenic Sarcoma RecurrentArmsIscador*P
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Systematic analysis of mistletoe prescriptions in clinical studies.Journal of cancer research and clinical oncology · 2023
    Pooled it
  4. MISTOSUS: a phase II trial ofFuture oncology (London, England) · 2026
    Trial
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alessandra LonghiChemotherapy Division, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.ORCID https://orcid.org/0000-0001-6708-3777
Marilena CesariChemotherapy Division, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Massimo SerraLaboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Erminia MarianiImmunoreumathology and Tissue Regeneration Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.ORCID https://orcid.org/0000-0002-4407-6707
Istituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn relapsed osteosarcoma, the 5-yr postrelapse disease-free survival (PRDFS) rate after the second relapse is <20%. In June 2007, a randomized study was started comparing oral etoposide vs

resultsOn 30 June 2019, at a median follow-up ITT of 83 months (range 3-144 ms), a median PRDFS of 106 ms (2-144) was observed in the

conclusionsAfter 12 years from the start of the trial, the patients in the

Identifiers

PMID32398946
PMCPMC7201820
OpenAlexW3018568383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.