Evidence map›Paper›PMID 32398822›Full record

ReviewNature reviews. Endocrinology2020

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.

Décio L Eizirik, Lorenzo Pasquali, Miriam Cnop

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 519 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
519citing papers in PubMed, 10 pooled it
87.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

519 citing papers in PubMed, 10 syntheses or guidelines pooled it, 805 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Procalcitonin and Diabetic Foot Ulcer Infections: A Meta-Analysis.Endocrinology, diabetes & metabolism · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

459 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Décio L EizirikULB Center for Diabetes Research, Welbio Investigator, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium. deizirik@ulb.ac.be.ORCID http://orcid.org/0000-0003-2453-5889
Lorenzo PasqualiEndocrine Regulatory Genomics, Department of Experimental & Health Sciences, University Pompeu Fabra, Barcelona, Spain. lorenzo.pasquali@upf.edu.ORCID http://orcid.org/0000-0003-2423-1826
Miriam CnopULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium. mcnop@ulb.ac.be.ORCID http://orcid.org/0000-0002-5112-1692
Université Libre de Bruxelles · BEUniversitat Pompeu Fabra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of functional β-cell mass is the key mechanism leading to the two main forms of diabetes mellitus - type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Understanding the mechanisms behind β-cell failure is critical to prevent or revert disease. Basic pathogenic differences exist in the two forms of diabetes mellitus; T1DM is immune mediated and T2DM is mediated by metabolic mechanisms. These mechanisms differentially affect early β-cell dysfunction and eventual fate. Over the past decade, major advances have been made in the field, mostly delivered by studies on β-cells in human disease. These advances include studies of islet morphology and human β-cell gene expression in T1DM and T2DM, the identification and characterization of the role of T1DM and T2DM candidate genes at the β-cell level and the endoplasmic reticulum stress signalling that contributes to β-cell failure in T1DM (mostly IRE1 driven) and T2DM (mostly PERK-eIF2α dependent). Here, we review these new findings, focusing on studies performed on human β-cells or on samples obtained from patients with diabetes mellitus.

Indexed as

AnimalsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Exocrine Pancreatic InsufficiencyHumansInsulin-Secreting CellsSignal Transduction

Identifiers

PMID32398822
OpenAlexW3024506005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.