Evidence map›Paper›PMID 32398793›Full record

ArticleScientific reports2020

Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue.

Jörg Reinders, Michael Altenbuchinger, Katharina Limm, Philipp Schwarzfischer, Tamara Scheidt, Lisa Strasser, Julia Richter, Monika Szczepanowski, Christian G Huber, Wolfram Klapper and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
  5. MCSPNature cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jörg Reinders *Chair and Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany. reinders@ifado.de.
Michael Altenbuchinger *Chair of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany.
Katharina LimmChair and Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany.ORCID http://orcid.org/0000-0001-9785-2338
Philipp SchwarzfischerChair and Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany.
Tamara ScheidtDepartment of Biosciences, Bioanalytical Research Labs, and Cancer Cluster Salzburg, University of Salzburg, 5020, Salzburg, Austria.
Lisa StrasserDepartment of Biosciences, Bioanalytical Research Labs, and Cancer Cluster Salzburg, University of Salzburg, 5020, Salzburg, Austria.
Julia RichterDepartment of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, 24106, Kiel, Germany.ORCID http://orcid.org/0000-0002-9543-4084
Monika SzczepanowskiDepartment of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, 24106, Kiel, Germany.
Christian G HuberDepartment of Biosciences, Bioanalytical Research Labs, and Cancer Cluster Salzburg, University of Salzburg, 5020, Salzburg, Austria.ORCID http://orcid.org/0000-0001-8358-1880
Wolfram KlapperDepartment of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, 24106, Kiel, Germany.ORCID http://orcid.org/0000-0001-7208-4117
Rainer SpangChair of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany.
Peter J OefnerChair and Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany.
University of Regensburg · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Salzburg · ATTU Dortmund University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of label-free nano-liquid chromatography - Sequential Window Acquisition of all THeoretical fragment-ion spectra - mass spectrometry (nanoLC-SWATH-MS) to the COO classification of DLBCL in formalin-fixed paraffin-embedded (FFPE) tissue. To generate a protein signature capable of predicting Affymetrix-based GCB scores, the summed log

Indexed as

B-LymphocytesCell LineageChromatography, LiquidFormaldehydeGene Expression ProfilingGerminal CenterHumansLymphoma, Large B-Cell, DiffuseMass SpectrometryNanotechnologyParaffin EmbeddingProteinsProteomeProteomicsTissue FixationFormaldehydeProteinsProteome

Identifiers

PMID32398793
PMCPMC7217957
OpenAlexW3024129428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.