Evidence map›Paper›PMID 32398758›Full record

ArticleNature communications2020

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.

Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny, Kristos I Negrón Terón, Zhao-Qing Luo, Peter S Brzovic, Rachel E Klevit, Chittaranjan Das

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases.Chembiochem : a European journal of chemical biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cocrystallization of ubiquitin-deubiquitinase complexes through disulfide linkage.Acta crystallographica. Section D, Structural biology · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Intracellular persister: A stealth agent recalcitrant to antibiotics.Frontiers in cellular and infection microbiology · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Interesting Biochemistries in the Structure and Function of Bacterial Effectors.Frontiers in cellular and infection microbiology · 2021
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kedar Puvar *Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0003-1788-2604
Shalini Iyer *Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.
Jiaqi FuPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Sebastian KennyDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0003-3541-2577
Kristos I Negrón TerónDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-6489-2699
Zhao-Qing LuoPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0001-8890-6621
Peter S Brzovic *Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Rachel E KlevitDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA. klevit@uw.edu.
Chittaranjan DasDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA. cdas@purdue.edu.ORCID http://orcid.org/0000-0002-0567-7753
Purdue University West Lafayette · USUniversity of Washington · US

Funding

Structural and Functional Characterization of BRCA1/BARD1R01GM088055 · NIGMS · UNIVERSITY OF WASHINGTON · PI KLEVIT, RACHEL E · 2009 to 2020
$6.5M
Mechanism of atypical ubiquitination and deubiquitination by bacterial effectorsR01GM126296 · NIGMS · PURDUE UNIVERSITY · PI Chittaranjan Das · 2018 to 2026
$3.6M
Effector-mediated Ubiquitin Manipulation in Legionella Pneumophila PathogenesisR01AI127465 · NIAID · PURDUE UNIVERSITY · PI Qing Deng · 2017 to 2026
$3.4M
Purdue University Molecular Biophysics Training ProgramT32GM132024 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon, John Tesmer · 2019 to 2026
$2.0M
NIAID NIH HHS R01 AI127465NIGMS NIH HHS R01 GM088055NIGMS NIH HHS R01 GM126296NIGMS NIH HHS T32 GM132024
6 · The paper itself

Abstract

The bacterial effector MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiquitin ligation, catalyzing formation of a γ-glutamyl-ε-Lys (Gln40

Indexed as

Bacterial ProteinsCatalytic DomainCloning, MolecularCrystallography, X-RayLegionella pneumophilaModels, MolecularMutagenesis, Site-DirectedProtein BindingProtein Structure, TertiaryRecombinant ProteinsSubstrate SpecificityTransglutaminasesUbiquitinUbiquitinationUbiquitin-Conjugating EnzymesBacterial ProteinsRecombinant ProteinsTransglutaminasesUBE2N protein, humanUbiquitinUbiquitin-Conjugating Enzymes

Identifiers

PMID32398758
PMCPMC7217864
OpenAlexW3024188993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.