ArticleInternational journal of obesity (2005)2020
Usefulness of surrogate markers to determine insulin action in fat cells.
Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Relationship between aerobic fitness and adipose tissue insulin resistance.American journal of physiology. Endocrinology and metabolism · 2026Pooled it
- The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms.Adipocyte · 2026Article
- Target tissue insulin resistance in early and late onset of overweight or obesity.International journal of obesity (2005) · 2026Article
- Effect of adipose tissue insulin resistance on substrate utilization during low-intensity exercise: a pilot study in young men.Journal of physical therapy science · 2026Article
- Relation Between Inflammatory Parameters and Insulin Resistance Indices in Cows During Early Lactation.Metabolites · 2025Article
- Mildly elevated liver lipid content is characterised by reduced insulin sensitivity.JHEP reports : innovation in hepatology · 2025Article
- Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test.Journal of the Endocrine Society · 2025Article
- Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1.International journal of obesity (2005) · 2024Article
- Associations of objectively measured physical activity, sedentary time and cardiorespiratory fitness with adipose tissue insulin resistance and ectopic fat.International journal of obesity (2005) · 2023Article
- Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2023Observational
- Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet.Frontiers in nutrition · 2023Article
- Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults.Frontiers in endocrinology · 2022Article
- Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a major factor behind insulin resistance. The validity of simple biochemical surrogate measures to estimate insulin resistance at the fat cell level is unclear.
objectiveTo investigate if the surrogate measures HOMA-IR (glucose/insulin product) and Adipo-IR (fatty acids/insulin product) reflect insulin action on glucose/lipid metabolism in fat cells.
designInsulin-induced lipogenesis and lipolysis inhibition (antilipolysis) in subcutaneous fat cells were investigated for sensitivity (reflecting receptor-near events) and responsiveness (i.e., maximum action reflecting distal post-receptor events) in 363 subjects. Results were compared with log
resultsIndividually, the four measures of in vitro insulin action on fat cells correlated significantly (p < 0.0001) but weakly with each other (adjusted r
conclusionsInsulin action at the receptor and post-receptor levels on lipolysis and lipogenesis in fat cells correlates significantly with Adipo-IR and HOMA-IR. Both surrogate measures give similar information about insulin resistance of glucose and lipid metabolism in fat cells.
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Registered trials
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