ArticleMolecular psychiatry2021
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Phenotypic Behavioural Effects of Genetic Deletion of the Vesicular Glutamate Transporter 3 in 5-Hydroxytryptamine Neurons.Genes, brain, and behavior · 2026Article
- Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood.Gastroenterology · 2025Article
- Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy.Cell reports · 2025Article
- Simultaneous detection of neurotransmitters and CuRSC advances · 2023Article
- Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals.Alcohol (Fayetteville, N.Y.) · 2021Article
- Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine.Scientific reports · 2021Article
- Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion.Neuropharmacology · 2021Review
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
- Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, potentially involving the dopamine system. Here, we show in the mouse that raphe nucleus serotonin neurons activate ventral tegmental area dopamine neurons via glutamate co-transmission and that this co-transmission is reduced in animals exposed postnatally to SSRIs. Blocking serotonin neuron glutamate co-transmission mimics this SSRI-induced hypolocomotion, while optogenetic activation of dopamine neurons reverses this hypolocomotor phenotype. Our data demonstrate that serotonin neurons modulate dopamine neuron activity via glutamate co-transmission and that this pathway is developmentally malleable, with high serotonin levels during early life reducing co-transmission, revealing the basis for the reduced novelty-induced exploration in adulthood due to postnatal SSRI exposure.
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