Observational studyNature communications2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.
Open access · goldAbstract readObservational Study
In one paragraph
Observational study in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder.Frontiers in neurology · 2024Pooled it
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- Preliminary evidence of neuroimmune system disruption in opioid use disorder: Findings from a pilot PET TSPO imaging study.Brain, behavior, & immunity - health · 2026Article
- Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain.Biological psychiatry · 2026Article
- Neuroimmune mechanisms in PTSD: inflammatory heterogeneity, circuit dysfunction, and biomarker-based subtypes.Molecular biology reports · 2026Review
- Inflammatory markers in the emergency department and PTSD symptoms in the AURORA Study: A longitudinal cohort study.Psychological medicine · 2026Article
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- Posttraumatic Stress Disorder and Handgrip Strength Among World Trade Center Firefighters and Emergency Medical Responders.International journal of environmental research and public health · 2026Article
- Astroglial and Neuronal Injury Markers (GFAP, UCHL-1, NfL, Tau, S100B) as Diagnostic and Prognostic Biomarkers in PTSD and Neurological Disorders.International journal of molecular sciences · 2026Review
- Neuroimaging evidence of mitochondrial dysfunction and inflammation in psychiatric disorders: a review.Psychoradiology · 2026Review
- Greater Neuroimmune System Deficit in Women Than Men With Alcohol Use Disorder.Biological psychiatry · 2026Article
- Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD.Molecular psychiatry · 2026Article
- Psychoinflammation: a conceptual framework for peripheral inflammatory phenotypes in mental health.Frontiers in psychiatry · 2026Article
- PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation.Molecular neurobiology · 2025Review
- Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory.Fundamental research · 2025Review
- Neurobiological and Existential Profiles in Posttraumatic Stress Disorder: The Role of Serotonin, Cortisol, Noradrenaline, and IL-12 Across Chronicity and Age.International journal of molecular sciences · 2025Article
- Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression.European archives of psychiatry and clinical neuroscience · 2025Review
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- The value of multimodal neuroimaging in the diagnosis and treatment of post-traumatic stress disorder: a narrative review.Translational psychiatry · 2025Review
- Research Progress on Inflammation and Immune Dysregulation in PTSD.Brain and behavior · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Shivani BhattInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA.ORCID http://orcid.org/0000-0003-3494-7246
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
Matthew J GirgentiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0003-1647-326X
Aleksandra RusowiczDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0002-8873-9875
Michael KapinosYale PET Center, Yale School of Medicine, New Haven, CT, 06519, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0001-8129-0051
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0001-7508-6572
Gustavo A AngaritaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Irina EsterlisInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA.
Margaret T DavisDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Steven M SouthwickDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Matthew J FriedmanNeurosciences Center, Dartmouth Medical School, Hanover, NH, 03755, USA.ORCID http://orcid.org/0000-0002-0497-6890
Traumatic Stress Brain Study Group
Ronald S DumanDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.ORCID http://orcid.org/0000-0001-8690-8439
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0002-9338-7966
John H KrystalDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Robert H PietrzakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06511, USA.
Kelly P CosgroveInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA. kelly.cosgrove@yale.edu.ORCID http://orcid.org/0000-0003-1351-9576
Yale Cancer Center · USYale University · USDartmouth College · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MImaging Microglial Activation in PTSD with PETR01MH110674 · NIMH · YALE UNIVERSITY · PI COSGROVE, KELLY P., PIETRZAK, ROBERT H · 2017 to 2020
$3.1MMultimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894kInvestigating the role of glucocorticoid function in PTSDF30MH116607 · NIMH · YALE UNIVERSITY · PI BHATT, SHIVANI · 2018 to 2020
$117kNCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIGMS NIH HHS T32 GM007205NIMH NIH HHS F30 MH116607NIMH NIH HHS R01 MH110674
Abstract
Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals with PTSD. [
Indexed as
AcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAAcetamidesAdaptor Proteins, Signal TransducingN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamidePyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14TNFRSF14 protein, humanTSPOAP1 protein, humanTSPO protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.