ArticleTranslational psychiatry2020
Genetic susceptibility, inflammation and specific types of depressive symptoms: evidence from the English Longitudinal Study of Ageing.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Differential associations of cataracts with somatic and cognitive-affective symptoms of depression: longitudinal findings from the English Longitudinal Study of Ageing.International ophthalmology · 2026Article
- Longitudinal trajectories of total, cognitive-affective, and somatic depressive symptoms in relation to hip fracture risk: evidence from the HRS and ELSA cohorts.Frontiers in public health · 2026Article
- Association between depressive symptom and respiratory health in two prospective cohort studies.NPJ primary care respiratory medicine · 2025Article
- Longitudinal trajectories of somatic and cognitive-affective depressive symptoms influence stroke risk across different populations: Three prospective cohort studies.World journal of psychiatry · 2025Article
- Five depressive symptom trajectories in three dimensions are risk factors of cancer: a ten-year follow-up study.Archives of public health = Archives belges de sante publique · 2025Article
- Persistently high and fluctuating trajectories of total and somatic depressive symptoms increase diabetes risk: Two prospective cohort studies.World journal of diabetes · 2025Article
- The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts.Frontiers in aging neuroscience · 2025Article
- Prospective longitudinal study of dynamic depressive symptom trajectories and diabetes onset risk in older adults: a 10-year follow-up of the HRS and ELSA cohorts.Frontiers in public health · 2025Article
- Eight-year total, cognitive-affective, and somatic depressive symptoms trajectories and risks of cardiac events.Translational psychiatry · 2024Article
- Measurement invariance of the Center for Epidemiological Studies-Depression scale and associations with genetic risk in older adults.PloS one · 2024Article
- Excess body weight and specific types of depressive symptoms: Is there a mediating role of systemic low-grade inflammation?Brain, behavior, and immunity · 2023Article
- Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression.Brain, behavior, & immunity - health · 2022Article
- Shared genetic loci between depression and cardiometabolic traits.PLoS genetics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic susceptibility to depression has been established using polygenic scores, but the underlying mechanisms and the potentially differential effects of polygenic scores on specific types of depressive symptoms remain unknown. This study examined whether systemic low-grade inflammation mediated the association between polygenic scores for depressive symptomatology (DS-PGS) and subsequent somatic versus cognitive-affective depressive symptoms. The sample consisted of 3510 men and women (aged 50+) recruited from the English Longitudinal Study of Ageing. DS-PGS were derived using the results of a recent genome-wide association study. Plasma C-reactive protein (CRP) was measured at wave 6 (2012/13). Depressive symptoms were assessed at wave 8 (2016/17), using the eight-item version of the Centre for Epidemiological Studies Depression Scale. Covariates (wave 2, 2004/05) included age, sex and ten principal components (PCs) to control for population stratification. Confirmatory factor analysis was performed to corroborate a previously identified two-factor structure of the CES-D, distinguishing between cognitive-affective and somatic symptoms. Longitudinal structural equation modelling was used to investigate the mediating role of CRP in the relationship between DS-PGS and cognitive-affective versus somatic symptoms. Our results showed that participants with a higher polygenic susceptibility to DS were significantly more likely to report cognitive-affective and somatic symptoms at follow-up. Mediation analyses revealed that CRP mediated the relationship between DS-PGS and somatic symptoms, but not the association between DS-PGS and cognitive-affective symptoms. These differential effects highlight the importance of considering individual differences in depression profiles in future studies. Ultimately, this will inform healthcare professionals to design more targeted treatments.
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