ArticleProceedings of the National Academy of Sciences of the United States of America2020
Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07339618 (Effects of Non-pharmacological Auditory and Somatosensory Stimulation on the Efficiency and Quality of Emergence From General Anesthesia), which is not on this map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Non-pharmacological Auditory and Somatosensory Stimulation on the Efficiency and Quality of Emergence From General Anesthesia
Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Review
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Human brain zero: uncovering the lowest neural state for consciousness engineering.Frontiers in neuroscience · 2026Article
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- "Schrödinger's Rat": Testing Consciousness Under Anesthesia Alters Brain State and Neuronal Responses in Auditory Cortex.Nature and science of sleep · 2026Article
- Pioneers and Pathfinders: 10 years of Frontiers in Medicine from t(ether)ed in-person medicine to untethered telemedicine.Frontiers in medicine · 2026Article
- Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2-Dependent Modulation of Subthreshold Currents.Journal of neurochemistry · 2026Article
- Intraoperative Music During General Anaesthesia in Dogs Undergoing Elective Ovariohysterectomy: A Prospective, Double-Blinded Randomized Exploratory Study.Animals : an open access journal from MDPI · 2025Article
- Proposed Physiological and Neurobiological Mechanisms of Music's Effect, with a Focus on the Perioperative Period: Literature Evidence from Human, Canine and Feline Medicine.Veterinary sciences · 2025Review
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- The neural activity of auditory conscious perception.NeuroImage · 2025Article
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- Music as a perioperative, non-pharmacological intervention in veterinary medicine. Establishing a feasible framework for music implementation and future perspectives with a focus on the perioperative period of dogs and cats.Frontiers in veterinary science · 2025Review
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.Cell reports · 2024Article
- Dynamic temporal neural patterns based on multichannel LFPs Identify different brain states during anesthesia in pigeons: comparison of three anesthetics.Medical & biological engineering & computing · 2024Article
- Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite its ubiquitous use in medicine, and extensive knowledge of its molecular and cellular effects, how anesthesia induces loss of consciousness (LOC) and affects sensory processing remains poorly understood. Specifically, it is unclear whether anesthesia primarily disrupts thalamocortical relay or intercortical signaling. Here we recorded intracranial electroencephalogram (iEEG), local field potentials (LFPs), and single-unit activity in patients during wakefulness and light anesthesia. Propofol infusion was gradually increased while auditory stimuli were presented and patients responded to a target stimulus until they became unresponsive. We found widespread iEEG responses in association cortices during wakefulness, which were attenuated and restricted to auditory regions upon LOC. Neuronal spiking and LFP responses in primary auditory cortex (PAC) persisted after LOC, while responses in higher-order auditory regions were variable, with neuronal spiking largely attenuated. Gamma power induced by word stimuli increased after LOC while its frequency profile slowed, thus differing from local spiking activity. In summary, anesthesia-induced LOC disrupts auditory processing in association cortices while relatively sparing responses in PAC, opening new avenues for future research into mechanisms of LOC and the design of anesthetic monitoring devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.