Evidence map›Paper›PMID 32398227›Full record

ArticleGenetics2020

Genetic Signatures of Evolutionary Rescue by a Selective Sweep.

Matthew M Osmond, Graham Coop

Abstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. How does genetic architecture affect eco-evolutionary dynamics? A theoretical perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew M OsmondCenter for Population Biology and Department of Evolution and Ecology, University of California, Davis, California 95616 mmosmond@ucdavis.edu.ORCID 0000-0001-6170-8182
Graham CoopCenter for Population Biology and Department of Evolution and Ecology, University of California, Davis, California 95616.ORCID 0000-0001-8431-0302

Funding

Genome-wide approaches to polygenic adaptationR01GM108779 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COOP, GRAHAM · 2014 to 2019
$1.0M
NIGMS NIH HHS R01 GM108779
6 · The paper itself

Abstract

One of the most useful models in population genetics is that of a selective sweep and the consequent hitch-hiking of linked neutral alleles. While variations on this model typically assume constant population size, many instances of strong selection and rapid adaptation in nature may co-occur with complex demography. Here, we extend the hitch-hiking model to evolutionary rescue, where adaptation and demography not only co-occur but are intimately entwined. Our results show how this feedback between demography and evolution determines-and restricts-the genetic signatures of evolutionary rescue, and how these differ from the signatures of sweeps in populations of constant size. In particular, we find rescue to harden sweeps from standing variance or new mutation (but not from migration), reduce genetic diversity both at the selected site and genome-wide, and increase the range of observed Tajima's

Indexed as

Evolution, MolecularModels, GeneticSelection, GeneticAdaptation, PhysiologicalAnimalsBiomassGene FrequencyGenetics, PopulationMutationbottleneckhitch-hikingpairwise diversitysoft sweepTajima’sD

Identifiers

PMID32398227
PMCPMC7337082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.