Evidence map›Paper›PMID 32398224›Full record

SynthesisGut2021

Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis.

Piyush Nathani, Purva Gopal, Nicole Rich, Adam Yopp, Takeshi Yokoo, Binu John, Jorge Marrero, Neehar Parikh, Amit G Singal

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 9 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 9 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Racial and Ethnic Disparities in Hepatocellular Carcinoma Treatment Receipt in the United States: A Systematic Review and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
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  7. Racial and Ethnic Disparities in Survival Among Patients With Hepatocellular Carcinoma in the United States: A Systematic Review and Meta-Analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
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  15. α/β for Hepatocellular Carcinoma Tumors Treated With Radiation Therapy.International journal of radiation oncology, biology, physics · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Piyush NathaniDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-4316-414X
Purva GopalDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Nicole RichDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Adam YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Takeshi YokooDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Binu JohnGastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VAMC, Richmond, Virginia, USA.
Jorge MarreroDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Neehar ParikhDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5874-9933
Amit G SingalDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA amit.singal@utsouthwestern.edu.
Southwestern Medical CenterSouthwestern Medical Center · USUniversity of Michigan · USVirginia Commonwealth University · US

Funding

Multilevel factors for racial/ethnic and socioeconomic disparities in prognosis of hepatocellular carcinomaR01MD012565 · NIMHD · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT, YOPP, ADAM · 2018 to 2022
$4.3M
Harms of Hepatocellular Carcinoma Screening in Patients with CirrhosisR01CA212008 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT · 2017 to 2022
$3.2M
Precision Screening for Hepatocellular Carcinoma in Patients with CirrhosisR01CA222900 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT · 2018 to 2023
$2.4M
NCI NIH HHS R01 CA212008NCI NIH HHS R01 CA222900NIMHD NIH HHS R01 MD012565
6 · The paper itself

Abstract

backgroundTumour growth patterns have important implications for surveillance intervals, prognostication and treatment decisions but have not been well described for hepatocellular carcinoma (HCC). The aim of our study was to characterise HCC doubling time and identify correlates for indolent and rapid growth patterns.

methodsWe performed a systematic literature review of Medline and EMBASE databases from inception to December 2019 and national meeting abstracts from 2010 to 2018. We identified studies reporting HCC tumour growth or tumour volume doubling time (TVDT), without intervening treatment, and abstracted data to calculate TVDT and correlates of growth patterns (rapid defined as TVDT <3 months and indolent as TVDT >9 months). Pooled TVDT was calculated using a random-effects model.

resultsWe identified 20 studies, including 1374 HCC lesions in 1334 patients. The pooled TVDT was 4.6 months (95% CI 3.9 to 5.3 months I

conclusionTVDT of HCC is approximately 4-5 months; however, there is heterogeneity in tumour growth patterns, including more aggressive patterns in Asian hepatitis B-predominant populations. Identifying correlates of tumour growth patterns is important to better individualise HCC prognostication and treatment decisions.

Indexed as

Tumor BurdenCarcinoma, HepatocellularDisease ProgressionHumansLiver NeoplasmsTime Factorshepatocellular carcinomaliver imagingmeta-analysis

Identifiers

PMID32398224
PMCPMC7657990
OpenAlexW3025561831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.