Evidence map›Paper›PMID 32398163›Full record

ArticleReproductive biology and endocrinology : RB&E2020

The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol.

Jonna Leppänen, Kaisa Randell, Ursula Schwab, Jussi Pihlajamäki, Leea Keski-Nisula, Tomi Laitinen, Seppo Heinonen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonna LeppänenDepartment of Obstetrics and Gynecology, Kuopio University Hospital and University of Eastern Finland, Puijonlaaksontie 2, FIN-70210, Kuopio, Finland. jonna.leppanen@kuh.fi.ORCID https://orcid.org/0000-0001-5201-295X
Kaisa RandellObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, PO Box 140, HUS 00029, Helsinki, Finland.
Ursula SchwabSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jussi PihlajamäkiSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Leea Keski-NisulaDepartment of Obstetrics and Gynecology, Kuopio University Hospital and University of Eastern Finland, Puijonlaaksontie 2, FIN-70210, Kuopio, Finland.
Tomi LaitinenDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FIN-70210, Kuopio, Finland.
Seppo HeinonenObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, PO Box 140, HUS 00029, Helsinki, Finland.
University of Eastern Finland · FIUniversity of Helsinki · FI

Funding

Kuopion Yliopistollinen Sairaala KUH5302463
6 · The paper itself

Abstract

backgroundThis study was made to figure out, does low and high estradiol levels during in vitro fertilization (IVF) cycles have a different effect on carotid artery distensibility (Cdis), carotid artery diameter (Cdia), blood pressure and metabolic factors? Can the stimulation protocol be considered safe to women's vasculature?

methodsWe studied 28 women having a long agonist protocol IVF-treatment in Kuopio University Hospital during the years 2011-2016. Patients were examined at three time points: in the beginning of their own period (low estradiol), during the gonadotrophin releasing hormone (GnRH) analogue downregulation (low estradiol) and during the follicle stimulating hormone (FSH) stimulation (high estradiol). Women served as their own controls and their menstrual phase (2- to 5-day period after the beginning of menstruation with low estrogen) was used as the reference. Cdis and Cdia were assessed using ultrasound. Blood pressure, weight, estradiol levels and lipids were monitored.

resultsCdis, Cdia, systolic and diastolic blood pressures peaked during the GnRH-analogue treatment with the lowest estradiol levels. Cdis, Cdia and systolic blood pressures declined by 11% (P = 0.002), 3,8% (P < 0.001) and 2,5% (P = 0.026) during the FSH-stimulation when the estradiol levels were high. Cdis correlated significantly (P < 0.05) with systolic blood pressure, diastolic blood pressure and triglycerides in high estrogenic environment and with diastolic blood pressure (P < 0.05) when estrogen profiles were low.

conclusionsCarotid artery stiffens during the high estradiol levels compared to low levels and this was not explained by the higher diameter of the carotid artery, hyperlipidemia or blood pressure profiles. All the changes in Cdis and Cdia are variations of normal, and if there is no history of cardiovascular problems, it can be considered, that the stimulation protocol is not hazardous to vasculature.

Indexed as

AdultBlood PressureBody WeightCarotid ArteriesEstradiolFemaleFertilization in VitroGonadotropin-Releasing HormoneHumansInfertility, FemaleOvulation InductionPregnancyPregnancy RateUltrasonographyYoung AdultEstradiolGonadotropin-Releasing HormoneCarotid arteryDistensibilityEstradiolInfertilityIn vitro fertilization

Identifiers

PMID32398163
PMCPMC7216631
OpenAlexW3025801679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.