Evidence map›Paper›PMID 32398160›Full record

Trial reportScandinavian journal of trauma, resuscitation and emergency medicine2020

Nitrous oxide/oxygen plus acetaminophen versus morphine in ST elevation myocardial infarction: open-label, cluster-randomized, non-inferiority study.

Sandrine Charpentier, Michel Galinski, Vincent Bounes, Agnès Ricard-Hibon, Carlos El-Khoury, Meyer Elbaz, François-Xavier Ageron, Stéphane Manzo-Silberman, Louis Soulat, Frédéric Lapostolle and 5 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scandinavian journal of trauma, resuscitation and emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02198378 (Analgesia of Acute Coronary Syndromes With ST-segment Elevation in a Pre-hospital Setting. Randomized Non-inferiority Trial of the Association MEOPA + Paracetamol Versus Morphine.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02198378 phase4completednot on this map

Analgesia of Acute Coronary Syndromes With ST-segment Elevation in a Pre-hospital Setting. Randomized Non-inferiority Trial of the Association MEOPA + Paracetamol Versus Morphine.

TypeinterventionalSponsorUniversity Hospital, ToulouseRan2014 to 2017Enrolled680ConditionsAcute Coronary SyndromeArmsMEOPA and paracetamol, Morphine
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review of Current Management of Myocardial Infarction.Journal of clinical medicine · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Sandrine CharpentierEmergency Department, Toulouse University Hospital, INSERM UMR 1027, University Toulouse III Paul Sabatier, Toulouse, France. charpentier.s@chu-toulouse.fr.
Michel GalinskiEmergency Department - SAMU 33, CHU de Bordeaux; INSERM U1219 - Injury Epidemiology Transport Occupation" team, University Bordeaux II, 33000, Bordeaux, France.
Vincent BounesSAMU31, Toulouse University Hospital; University Toulouse III Paul Sabatier, Toulouse, France.
Agnès Ricard-HibonPôle Emergency Department, SAMU - Centre Hospitalier René Dubos Pontoise, 95300, Pontoise, France.
Carlos El-KhouryEmergency Department and RESCUe Network, Lucien Hussel Hospital, Vienne, France.
Meyer ElbazDepartment of Cardiology, Rangueil University Hospital, Toulouse, France.
François-Xavier AgeronEmergency Department, Centre Hospitalier Annecy Genevois, Annecy, France.
Stéphane Manzo-SilbermanCardiology department, Lariboisire Hospital, APHP, Paris, France.
Louis SoulatSAMU 35 SMUR Urgences adultes, Centre Hospitalier Universitaire Rennes, Université Rennes 1, Rennes, France.
Frédéric LapostolleSAMU 93 - UF Recherche-Enseignement-Qualité Université Paris 13, Sorbonne Paris Cité, Inserm U942 Hôpital Avicenne, AP-HP, 125, rue de Stalingrad, 93009, Bobigny, France.
Alexandre GérardHospices Civils de Lyon SAMU 69 - Hôpital Édouard HERRIOT 5, place d'Arsonval, 69437, LYON Cedex 03, France.
Delphine BregeaudHospital Centre of Chateauroux, Chateauroux, France.
Vanina BongardDepartment of Epidemiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Eric Bonnefoy-CudrazHôpital cardiologique Louis-Pradel, 69500, Lyon, France.
SCADOL II investigators
Université Claude Bernard Lyon 1 · FRUniversité Toulouse III - Paul Sabatier · FRUniversité Paris Cité · FRDélégation Paris 5 · FRHealth Services and Performance Research Laboratory · FRHôpital Lariboisière · FRHôpital Rangueil · FRHospices Civils de Lyon · FRLaboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps · FRSanté Publique France · FR

Funding

Ministère des Solidarités et de la Santé, France PHRC2013
6 · The paper itself

Abstract

backgroundStudies have shown disparate results on the consequences of morphine use in ST-segment elevation myocardial infarction (STEMI). No study has evaluated alternative treatments that could be at least non-inferior to morphine without its potentially damaging consequences for myocardial function and platelet reactivity. The aim of this study was to evaluate whether nitrous oxide/oxygen plus intravenous acetaminophen (NOO-A) is non-inferior to morphine to control chest pain in STEMI patients.

methodsThis multicenter, open-label, cluster-randomized, controlled, non-inferiority study compared NOO-A with morphine in 684 prehospital patients with ongoing suspected STEMI of < 12 h duration and a pain rating score ≥ 4. The primary endpoint was the proportion of patients achieving pain relief (numeric rating score ≤ 3) after 30 min. Secondary safety endpoints included serious adverse events and death at 30 days.

resultsThe median baseline pain score was 7.0 in both groups. The primary endpoint occurred in 51.7% of the NOO-A group and 73.6% of the morphine group (absolute risk difference - 21.7%; 95% confidence interval - 29.6 to - 13.8). At 30 days, the rate of serious adverse events was 16.0 and 18.8% in the NOO-A and morphine groups respectively (p = NS). The rate of death was 1.8% (NOO-A group) and 3.8% (morphine group) (p = NS).

conclusionAnalgesia provided by NOO-A was inferior to morphine at 30 min in patients with acute STEMI in the prehospital setting. Rates of serious adverse events did not differ between groups.

trial registrationClinicalTrials.gov: NCT02198378.

Indexed as

AcetaminophenAdministration, InhalationAnalgesics, Non-NarcoticAnalgesics, OpioidChest PainDose-Response Relationship, DrugDrug Therapy, CombinationFemaleHumansInjections, IntravenousMaleMiddle AgedMorphineNitrous OxideOxygenOxygen Inhalation TherapyAcetaminophenAnalgesics, Non-NarcoticAnalgesics, OpioidMorphineNitrous OxideOxygenAnalgesia, prehospitalST-segment elevation myocardial infarction

Identifiers

PMID32398160
PMCPMC7218609
OpenAlexW3026818222

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.