ArticleVeterinary research2020
RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response.
Article in Veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- The Regulation of Oxidative Stress Is a Conserved Response to RNA Virus Infection in Fish.Antioxidants (Basel, Switzerland) · 2026Article
- Deciphering European Sea Bass (International journal of molecular sciences · 2025Article
- Genome-wide identification, characterization and expression analysis of CNGC Genes in moso bamboo (Phyllostachys edulis).BMC plant biology · 2025Article
- Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass.BMC biology · 2025Article
- Comparative Analysis of Immune Gene Transcription in Sea Bream (Pathogens (Basel, Switzerland) · 2024Article
- Identification and functional characterization of fish IL-17 receptors suggest important roles in the response to nodavirus infection.Marine life science & technology · 2024Article
- Genome-wide identification and expression analysis of the HAK/KUP/KT gene family in Moso bamboo.Frontiers in plant science · 2024Article
- Whole-genome sequencing identifies interferon-induced protein IFI6/IFI27-like as a strong candidate gene for VNN resistance in European sea bass.Genetics, selection, evolution : GSE · 2023Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- Transcriptomic Analysis of Fish Hosts Responses to Nervous Necrosis Virus.Pathogens (Basel, Switzerland) · 2022Review
- Zebrafish as a Vertebrate Model for Studying Nodavirus Infections.Frontiers in immunology · 2022Article
- Article
- Multifactorial Causes of Chronic Mortality in Juvenile Sturgeon (Animals : an open access journal from MDPI · 2020Article
- Potential Involvement of lncRNAs in the Modulation of the Transcriptome Response to Nodavirus Challenge in European Sea Bass (Biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Nodavirus, or nervous necrosis virus (NNV), is the causative agent of viral encephalopathy and retinopathy (VER), a severe disease affecting numerous fish species worldwide. European sea bass, a cultured species of great economic importance, is highly susceptible to the disease. To better understand the response of this organism to NNV, we conducted RNA-Seq analysis of the brain and head kidney from experimentally infected and uninfected sea bass juveniles at 24 and 72 hours post-infection (hpi). Contrary to what was expected, we observed modest modulation of immune-related genes in the brain, the target organ of this virus, and some of these genes were even downregulated. However, genes involved in the stress response showed extremely high modulation. Accordingly, the genes encoding the enzymes implicated in the synthesis of cortisol were almost the only overexpressed genes in the head kidney at 24 hpi. This stress response was attenuated after 72 h in both tissues, and a progressive immune response against the virus was mounted. Moreover, experiments were conducted to determine how stress activation could impact NNV replication. Our results show the complex interplay between viral activity, the stress reaction and the immune response.
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