ArticleMalaria journal2020
Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia.
Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
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67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Urban malaria and population mobility in sub-Saharan Africa: systematic review and meta-analysis.Malaria journal · 2025Pooled it
- A quantitative and systematic analysis of Anopheles stephensi bionomics and control approaches.Acta tropica · 2024Pooled it
- Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region.Malaria journal · 2020Pooled it
- Field evaluation of SumiLarvMalaria journal · 2026Article
- Ovicidal and larvicidal activity of the Impatiens rothii and Salvia officinalis extracts against Anopheles stephensi (Culicidae: Diptera) in laboratory conditions.Malaria journal · 2026Article
- Article
- Susceptibility ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Habitat heterogeneity and green filamentous algae influence the larval ecology of Anopheles stephensi during the dry season in Eastern Ethiopia.Parasites & vectors · 2025Article
- Modeling urban malaria infection in Anopheles stephensi hotspot area in Eastern Ethiopia: application of Structural Equation Modeling.BMC infectious diseases · 2025Article
- Anopheles stephensi larval habitat superproductivity and its relevance for larval source management in Ethiopia.Malaria journal · 2025Article
- Impact of Omics Studies on Understanding Insecticide Resistance Mechanisms in Sub-Saharan Malaria Vectors: A Systematic Review.Journal of arthropod-borne diseases · 2025Review
- Bionomics of Anopheles stephensi across the urban-rural landscapes of Eastern Ethiopia.Malaria journal · 2025Article
- Susceptibility of the invasive malaria vector Anopheles stephensi in Ethiopia to novel chemical insecticides and insect growth regulator.Scientific reports · 2025Article
- Genomics of urban adaptation and exaptation in mosquitoes and consequences for vectorial capacity.Current opinion in insect science · 2025Review
- Emerging challenges for mosquito-borne disease control and the promise of symbiont-based transmission-blocking strategies.PLoS pathogens · 2025Review
- Larvicidal and adulticidal effects of Ethiopian medicinal plants against Anopheles gambiae (Diptera: Culicidae).Malaria journal · 2025Article
- First detection and entomological characterisation of invasive malaria vector Anopheles stephensi in sympatry with other vectors in Gayi Southern Niger Republic.Scientific reports · 2025Article
- Evaluation of the effectiveness of Aquatain, Bacillus thuringiensis var. israelensis, and Temephos on Anopheles arabiensis and Anopheles stephensi larvae in the laboratory and field settings.Parasites & vectors · 2025Article
- Spatial distribution and population structure of the invasive Anopheles stephensi in Kenya from 2022 to 2024.Scientific reports · 2025Article
- Genome Structural Variants Shape Adaptive Success of an Invasive Urban Malaria Vector Anopheles stephensi.Molecular biology and evolution · 2025Article
7 more citing papers are in PubMed but not listed here.
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7 authors at 6 institutions in 2 countries.
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Abstract
backgroundThe movement of malaria vectors into new areas is a growing concern in the efforts to control malaria. The recent report of Anopheles stephensi in eastern Ethiopia has raised the necessity to understand the insecticide resistance status of the vector in the region to better inform vector-based interventions. The aim of this study was to evaluate insecticide resistance in An. stephensi in eastern Ethiopia using two approaches: (1) World Health Organization (WHO) bioassay tests in An. stephensi; and (2) genetic analysis of insecticide resistance genes in An. stephensi in eastern Ethiopia.
methodsMosquito larvae and pupae were collected from Kebri Dehar. Insecticide susceptibility of An. stephensi was tested with malathion 5%, bendiocarb 0.1%, propoxur 0.1%, deltamethrin 0.05%, permethrin 0.75%, pirimiphos-methyl 0.25% and DDT 4%, according to WHO standard protocols. In this study, the knockdown resistance locus (kdr) in the voltage gated sodium channel (vgsc) and ace1R locus in the acetylcholinesterase gene (ace-1) were analysed in An. stephensi.
resultsAll An. stephensi samples were resistant to carbamates, with mortality rates of 23% and 21% for bendiocarb and propoxur, respectively. Adult An. stephensi was also resistant to pyrethroid insecticides with mortality rates 67% for deltamethrin and 53% for permethrin. Resistance to DDT and malathion was detected in An. stephensi with mortality rates of 32% as well as An. stephensi was resistance to pirimiphos-methyl with mortality rates 14%. Analysis of the insecticide resistance loci revealed the absence of kdr L1014F and L1014S mutations and the ace1R G119S mutation.
conclusionOverall, these findings support that An. stephensi is resistant to several classes of insecticides, most notably pyrethroids. However, the absence of the kdr L1014 gene may suggest non-target site resistance mechanisms. Continuous insecticide resistance monitoring should be carried out in the region to confirm the documented resistance and exploring mechanisms conferring resistance in An. stephensi in Ethiopia.
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