ArticleBMC oral health2020
Matrix metalloproteinases gene variants and dental caries in Czech children.
Article in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- [Polymorphisms associated with dental caries in pediatric populations: a systematic review].Revista medica del Instituto Mexicano del Seguro Social · 2023Pooled it
- The Effect of Genetics on Caries Risk Assessment: MMP3 (rs679620) and VDR (rs731236) Gene Polymorphisms.Oral health & preventive dentistry · 2026Article
- Allelic and Genotypic Distribution ofClinics and practice · 2025Article
- The Effects of MMP3 (rs679620) and VDR (rs731236) Gene Polymorphisms on Dental Caries: A Pilot Study.European journal of dentistry · 2025Article
- The association betweenHealth science reports · 2023Article
- Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.International journal of molecular sciences · 2022Review
- The association between genetic polymorphisms in matrix metalloproteinases and caries experience.Clinical oral investigations · 2021Article
- Association of polymorphisms in genes involved in enamel formation, taste preference and immune response with early childhood caries in Saudi pre-school children.Saudi journal of biological sciences · 2021Article
- Prediction of Early Childhood Caries Based on Single Nucleotide Polymorphisms Using Neural Networks.Genes · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMatrix metalloproteinases (MMPs) play an important role in tooth formation and the mineralization of dental tissue. The aim of the study was to analyse Czech children with primary/permanent dentition polymorphisms in those genes encoding MMP2, MMP3, MMP9, MMP13, MMP16, and MMP20, which had been previously associated with dental caries in other populations.
methodsIn total, 782 Czech children were included in this case-control study. DNA samples were taken from 474 subjects with dental caries (with decayed/missing/filled teeth, DMFT ≥ 1) and 155 caries free children (DMFT = 0) aged 13-15 years, as well as 101 preschool children with early childhood caries (ECC, dmft ≥ 1) and 52 caries free children (dmft = 0), were analyzed for nine MMPs single nucleotide polymorphisms (SNPs) using real time polymerase chain reaction TaqMan assays.
resultsThere were no significant differences in the allele and/or genotype frequencies of all the studied MMPs SNPs among children with dental caries in primary/permanent dentition and the healthy controls (P > 0.05). In addition, similar allele or genotype frequencies of the studied MMPs SNPs were found in children with severe dental caries in their permanent teeth (children with DMFT ≥ 6) and the healthy controls (DMFT = 0, P > 0.05).
conclusionsThis study demonstrated the lack of association between the selected SNPs in candidate genes of MMPs and the susceptibility to or severity of dental caries in both primary and permanent dentitions in Czech children.
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