ArticleAntibiotics (Basel, Switzerland)2020
Identification and Rational Design of a Novel Antibacterial Peptide Dermaseptin-AC from the Skin Secretion of the Red-Eyed Tree Frog
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- An integrative review of wound healing: anatomy, molecular mediators, and indigenous therapies.Molecular biology reports · 2026Review
- Antibacterial activity of peptide derivatives of dermaseptins against multidrug-resistantBiochemistry and biophysics reports · 2026Article
- Engineering of a Novel Amphibian Skin Peptide Isolated from Agua Rica Leaf Frog (Antibiotics (Basel, Switzerland) · 2025Article
- Enhancing the selectivity and conditional sensitivity of an antimicrobial peptide through cleavage simulations and homoarginine incorporation to combat drug-resistant bacteria.Scientific reports · 2025Article
- Thinking on the Construction of Antimicrobial Peptide Databases: Powerful Tools for the Molecular Design and Screening.International journal of molecular sciences · 2023Review
- First generation of multifunctional peptides derived from latarcin-3a fromFrontiers in microbiology · 2022Article
- Article
- Exploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.Antibiotics (Basel, Switzerland) · 2021Article
- Design and heterologous expression of a novel dimeric LL37 variant in Pichia pastoris.Microbial cell factories · 2021Article
- Identification of Distinct Characteristics of Antibiofilm Peptides and Prospection of Diverse Sources for Efficacious Sequences.Frontiers in microbiology · 2021Article
- Development of Antimicrobial Peptides from Amphibians.Antibiotics (Basel, Switzerland) · 2020Article
- Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant AntAntibiotics (Basel, Switzerland) · 2020Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance represents a tremendous contemporary clinical challenge. Given this challenge, antimicrobial peptides (AMPs) are regarded as one of the most promising new options for next-generation lead antibiotics. Here, we describe the antibacterial activities of a cationic peptide named DRP-AC4, obtained from frog skin secretion using shotgun cloning. Two modified peptides were derived by substituting the sequence of amino acids to complete the hydrophobic face (DRP-AC4b) and increase net charge (DRP-AC4a), respectively. The activity and cytotoxicity of these two peptides were compared. DRP-AC4a displayed significantly increased potency against bacteria compared to the natural peptide. It should be noted, however, that both analogue peptides demonstrated higher lytic ability than the natural peptide against the membranes of mammalian erythrocytes. At the same time, all three peptides displayed lower hemolytic activity compared to their antibacterial activity. Here, we demonstrate that AMPs have more complex activity mechanisms and faster bactericidal rates than traditional antibiotics, which may be one of the reasons why bacteria do not develop resistance to them. These discoveries provide interesting insights into the discovery and development of novel drugs from natural sources.
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