ArticleNutrients2020
Biomarkers and Hematological Indices in the Diagnosis of Iron Deficiency in Children with Inflammatory Bowel Disease.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Dermatological Manifestations in Pediatric Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center.Clinical and experimental pediatrics · 2025Article
- Early and simple laboratory markers of poor outcome in children with inflammatory bowel disease.Archives of medical science : AMS · 2025Article
- Iron Status of Preadolescents Without Clinical Pallor Attending a Tertiary Care Hospital in South India- A Cross-Sectional Analytical Study.Indian journal of pediatrics · 2024Article
- Prevalence and Factors Associated with Iron Deficiency Anaemia among Children Aged 6-23 Months in Southwestern Uganda.International journal of pediatrics · 2024Article
- Diagnostic Accuracy of Hemoglobin Levels and Red Blood Cell Parameters for Iron Deficiency in Adolescents: A Cross-Sectional Study.Global pediatric health · 2024Article
- Performance of Machine Learning Algorithms for Predicting Disease Activity in Inflammatory Bowel Disease.Inflammation · 2023Article
- Implication of asymptomatic and clinical Plasmodium falciparum infections on biomarkers of iron status among school-aged children in Malawi.Malaria journal · 2022Article
- Prevalence of Anemia, Iron Deficiency, Iron Deficiency Anemia and Diagnostic Performance of Hematologic and Biochemical Markers of Sideropenia in 1- to 5-Year-Old Children in Thrace Greece.Mediterranean journal of hematology and infectious diseases · 2022Article
- Nutritional Aspects of Pediatric Gastrointestinal Diseases.Nutrients · 2021Review
- Effect of Iron Deficiency on Short-Term Response to Treatment in Cats With Chronic Enteropathies.Journal of veterinary internal medicineArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation may affect many routinely available parameters of iron homeostasis. Thus, the recognition of iron deficiency in inflammatory bowel disease (IBD) remains a diagnostic challenge in a clinical routine. The aim of the study was to detect the most efficient marker of iron deficiency in IBD children. In a group of 75 IBD children, we evaluated the sensitivity, specificity, accuracy, and positive and negative predictive values of erythrocytes' indices, including MCV, MCH, MCHC and RDW, and biochemical markers, including iron, transferrin, sTfR and sTfR/log ferritin, for identifying iron deficiency. Receiver operating characteristic (ROC) analysis was used to compare the ability of these parameters to detect iron deficiency. The best predictors of iron deficiency were sTfR/log ferritin, with accuracy 0.86, sensitivity 0.98, specificity 0.63, positive predictive value 0.83 and negative predictive value 0.94, and sTfR, with accuracy 0.77, sensitivity 0.82, specificity 0.67, positive predictive value 0.82 and negative predictive value 0.67. Moreover, sTfR/log ferritin exhibited the largest area under ROC (0.922), followed by sTfR (0.755) and MCH (0.720). The sTfR/log ferritin index appears to be the most efficient marker of iron depletion in pediatric IBD, and it may give an added value in the management of IBD patients.
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