Evidence map›Paper›PMID 32397494›Full record

ArticleCells2020

Truncated Pneumolysin from

Shun-Fu Chang, Cheng-Nan Chen, Jung-Chung Lin, Hsin-Ell Wang, Shigetarou Mori, Jia-Je Li, Chia-Kuang Yen, Ching-Yun Hsu, Chang-Phone Fung, Pele Choi-Sing Chong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Shun-Fu ChangDepartment of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0002-2276-7785
Cheng-Nan ChenDepartment of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan.
Jung-Chung LinDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Hsin-Ell WangDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Shigetarou MoriDepartment of Bacteriology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Jia-Je LiDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Chia-Kuang YenDepartment of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan.
Ching-Yun HsuDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Chang-Phone FungSection of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Pele Choi-Sing ChongGraduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan.
Chih-Hsiang LengNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350, Taiwan.
Yi-Jun DingNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350, Taiwan.
Feng-Yee ChangDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
L Kristopher SiuDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Tri-Service General Hospital · TWNational Chiayi University · TWNational Health Research Institutes · TWChiayi Chang Gung Memorial Hospital · TWChina Medical University · TWNational Institute of Infectious Diseases · JPNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial proteins have recently been found to have more benefits in clinical disease treatment because of their better-developed strategy and properties than traditional medicine. In this study, we investigated the effectiveness of a truncated peptide synthesized from the C-terminal sequence of pneumolysin, i.e., C70PLY4, in

Indexed as

Amino Acid SequenceAnimalsApoptosisBacterial ProteinsBinding SitesCaspase 3Cell SurvivalDiet, High-FatE-SelectinExtracellular Signal-Regulated MAP KinasesHumansHuman Umbilical Vein Endothelial CellsInflammationIntercellular Adhesion Molecule-1LipopolysaccharidesMiceBacterial ProteinsCaspase 3E-SelectinExtracellular Signal-Regulated MAP KinasesIntercellular Adhesion Molecule-1LipopolysaccharidesMutant ProteinsNF-kappa BplY protein, Streptococcus pneumoniaeStreptolysinsStreptozocinToll-Like Receptor 4Vascular Cell Adhesion Molecule-1chronic inflammatory diseasemicrobial proteinneutrophil activationpneumolysinToll-like receptor 4

Identifiers

PMID32397494
PMCPMC7290803
OpenAlexW3022809862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.