Evidence map›Paper›PMID 32397326›Full record

ArticleMolecules (Basel, Switzerland)2020

Efficient and Divergent Enantioselective Syntheses of DHPVs and Anti-Inflammatory Effect on IEC-6 Cells.

Hyun Su Kim, Sungkyun Chung, Moon-Young Song, Changjin Lim, Hyeyoung Shin, Joonseong Hur, Hyuk Kwon, Young-Ger Suh, Eun-Hee Kim, Dongyun Shin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hyun Su KimDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Sungkyun ChungDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Moon-Young SongDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Changjin LimSchool of Pharmacy, Jeonbuk National University, Jeonju 54896, Korea.
Hyeyoung ShinDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Joonseong HurNatural Products Research Institute, Korea Institute of Science and Technology (KIST), 679 Saimdang-ro, Gangneung 25451, Korea.
Hyuk KwonDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Young-Ger SuhDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Eun-Hee KimDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.ORCID 0000-0002-8523-0440
Dongyun ShinCollege of Pharmacy, Gachon University, 191 Hambangmoe-ro, Yeonsu-gu, Incheon 21936, Korea.
Seok-Ho KimDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.ORCID 0000-0002-2494-751X
CHA University · KRGachon University · KRJeonbuk National University · KRKorea Institute of Science and Technology · KR

Funding

National Research Foundation of Korea NRF-2017R1D1A1B03034612
6 · The paper itself

Abstract

Despite numerous reports on the beneficial effects of catechin or epicatechin contained in tea and cacao extract on human health, a conclusive and precise molecular mechanism has not been elucidated. Metabolism of chemical compounds in gut microbiota recently gained significant attention, and extensive studies have been devoted in this field. In conjunction with these results, our group focused on the anti-inflammatory effects of both enantiomers of DHPV (5-(3',4'-dihydroxyphenyl)-γ-valerolactone), produced in the intestine by microbiota metabolism, on IEC-6 cells. Divergent and efficient enantioselective synthesis of (

Indexed as

Anti-Inflammatory AgentsAnimalsCell LineInflammatory Bowel DiseasesIntestinal MucosaLactonesRatsAnti-Inflammatory Agentsgamma-valerolactoneLactonesanti-inflammatory effectasymmetric dihydroxylationDHPVdivergent synthesisIκBαNF-κB

Identifiers

PMID32397326
PMCPMC7248962
OpenAlexW3022078836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.