Evidence map›Paper›PMID 32397300›Full record

ArticleInternational journal of molecular sciences2020

A Synergistic Effect of Reactive Oxygen and Reactive Nitrogen Species in Plasma Activated Liquid Media Triggers Astrocyte Wound Healing.

Eloisa Sardella, Maria Grazia Mola, Roberto Gristina, Monica Piccione, Valeria Veronico, Manuela De Bellis, Antonio Cibelli, Maura Buttiglione, Vincenza Armenise, Pietro Favia and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eloisa SardellaInstitute of Nanotechnology, National Research Council of Italy (CNR-NANOTEC), c/o Department of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.
Maria Grazia MolaDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
Roberto GristinaInstitute of Nanotechnology, National Research Council of Italy (CNR-NANOTEC), c/o Department of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.
Monica PiccioneDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
Valeria VeronicoDepartment of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.
Manuela De BellisDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
Antonio CibelliDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
Maura ButtiglioneDepartment of Biomedical Sciences and Human Oncology, Medical School, University of Bari Aldo Moro, 70124 Bari, Italy.
Vincenza ArmeniseDepartment of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.
Pietro FaviaInstitute of Nanotechnology, National Research Council of Italy (CNR-NANOTEC), c/o Department of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.
Grazia Paola NicchiaDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, Italy.
University of Bari Aldo Moro · ITIstituto di Nanotecnologia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocyte proliferation and migration toward injured Central Nervous System (CNS) areas are key features of astrogliosis and glial scar formation. Even though it is known that intracellular and environmental Reactive Oxygen and Nitrogen Species (RONS) affect astrocyte behaviour in physiological and pathophysiological conditions, their effects on the migration and growth of astrocytes are still unclear. Plasma-technologies are emerging in medicine as a tool to generate RONS for treating cells directly or through Plasma Activated Liquid Media (PALM). In this paper, we show for the first time how the use of PALM can modulate both astrocyte growth and migration as a function of active species produced by plasma in liquids. Our results show that PALM, generated by means of cold atmospheric pressure plasmas fed with N

Indexed as

AnimalsAquaporin 4AstrocytesCell MovementCell ProliferationCells, CulturedConnexin 43Glial Fibrillary Acidic ProteinHydrogen PeroxideRatsRats, WistarReactive Nitrogen SpeciesReactive Oxygen SpeciesWound HealingAquaporin 4Connexin 43Gfap protein, ratGja1 protein, ratGlial Fibrillary Acidic ProteinHydrogen PeroxideReactive Nitrogen SpeciesReactive Oxygen Speciesastrocytesoxidative stressplasma activated mediumwound healing

Identifiers

PMID32397300
PMCPMC7247562
OpenAlexW3021782929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.