Evidence map›Paper›PMID 32397286›Full record

ArticleBiology2020

Using Early Data to Estimate the Actual Infection Fatality Ratio from COVID-19 in France.

Lionel Roques, Etienne K Klein, Julien Papaïx, Antoine Sar, Samuel Soubeyrand

Abstract read
In one paragraph

Article in Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review and meta-analysis of published research data on COVID-19 infection fatality rates.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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  18. A Bayesian estimate of the early COVID-19 infection fatality ratio in Brazil based on a random seroprevalence survey.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lionel RoquesINRAE, BioSP, 84914 Avignon, France.ORCID 0000-0001-6647-7221
Etienne K KleinINRAE, BioSP, 84914 Avignon, France.
Julien PapaïxINRAE, BioSP, 84914 Avignon, France.
Antoine SarMedicentre Moutier, 2740 Moutier, Switzerland.
Samuel SoubeyrandINRAE, BioSP, 84914 Avignon, France.

Funding

INRAE MEDIA
6 · The paper itself

Abstract

The number of screening tests carried out in France and the methodology used to target the patients tested do not allow for a direct computation of the actual number of cases and the infection fatality ratio (IFR). The main objective of this work is to estimate the actual number of people infected with COVID-19 and to deduce the IFR during the observation window in France. We develop a `mechanistic-statistical' approach coupling a SIR epidemiological model describing the unobserved epidemiological dynamics, a probabilistic model describing the data acquisition process and a statistical inference method. The actual number of infected cases in France is probably higher than the observations: we find here a factor ×8 (95%-CI: 5-12) which leads to an IFR in France of 0.5% (95%-CI: 0.3-0.8) based on hospital death counting data. Adjusting for the number of deaths in nursing homes, we obtain an IFR of 0.8% (95%-CI: 0.45-1.25). This IFR is consistent with previous findings in China (0.66%) and in the UK (0.9%) and lower than the value previously computed on the Diamond Princess cruse ship data (1.3%).

Indexed as

Bayesian inferencecase fatality rateCOVID-19infection fatality ratiomechanistic-statistical modelSIR model

Identifiers

PMID32397286
PMCPMC7284549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.