Evidence map›Paper›PMID 32397264›Full record

ReviewDiagnostics (Basel, Switzerland)2020

Magnetic Lateral Flow Immunoassays.

Amanda Moyano, Esther Serrano-Pertierra, María Salvador, José Carlos Martínez-García, Montserrat Rivas, M Carmen Blanco-López

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. FeMikrochimica acta · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. CRISPR-assisted MoSMikrochimica acta · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Recent Advancements in Technologies to Detect EnterohaemorrhagicJournal of microbiology and biotechnology · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amanda MoyanoDepartment of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/ Julián Clavería 8, 33006 Oviedo, Spain.
Esther Serrano-PertierraDepartment of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/ Julián Clavería 8, 33006 Oviedo, Spain.
María SalvadorDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33204 Gijon, Spain.
José Carlos Martínez-GarcíaDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33204 Gijon, Spain.
Montserrat RivasDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33204 Gijon, Spain.
M Carmen Blanco-LópezDepartment of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/ Julián Clavería 8, 33006 Oviedo, Spain.

Funding

Gobierno del Principado de Asturias BP17-152Gobierno del Principado de Asturias IDI/2018/000185Ministerio de Economía, Industria y Competitividad, Gobierno de España MAT2017-84959-C2-1-R
6 · The paper itself

Abstract

A new generation of magnetic lateral flow immunoassays is emerging as powerful tool for diagnostics. They rely on the use of magnetic nanoparticles (MNP) as detecting label, replacing conventional gold or latex beads. MNPs can be sensed and quantified by means of external devices, allowing the development of immunochromatographic tests with a quantitative capability. Moreover, they have an added advantage because they can be used for immunomagnetic separation (IMS), with improvements in selectivity and sensitivity. In this paper, we have reviewed the current knowledge on magnetic-lateral flow immunoassay (LFIA), coupled with both research and commercially available instruments. The work in the literature has been classified in two categories: optical and magnetic sensing. We have analysed the type of magnetic nanoparticles used in each case, their size, coating, crystal structure and the functional groups for their conjugation with biomolecules. We have also taken into account the analytical characteristics and the type of transduction. Magnetic LFIA have been used for the determination of biomarkers, pathogens, toxins, allergens and drugs. Nanocomposites have been developed as alternative to MNP with the purpose of sensitivity enhancement. Moreover, IMS in combination with other detection principles could also improve sensitivity and limit of detection. The critical analysis in this review could have an impact for the future development of magnetic LFIA in fields requiring both rapid separation and quantification.

Indexed as

lateral flow immunoassaymagnetic biosensorsmagnetic nanoparticlesmagnetic transductionnanocompositesoptical transduction

Identifiers

PMID32397264
PMCPMC7278001

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.