Evidence map›Paper›PMID 32397012›Full record

ArticleJournal of audiology & otology2020

A Gap Prepulse with a Principal Stimulus Yields a Combined Auditory Late Response.

Jae-Hun Lee, Jae Yun Jung, Ilyong Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of audiology & otology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jae-Hun LeeBeckman Laser Institute Korea, College of Medicine, Dankook University, Cheonan, Korea.
Jae Yun JungBeckman Laser Institute Korea, College of Medicine, Dankook University, Cheonan, Korea.
Ilyong ParkBeckman Laser Institute Korea, College of Medicine, Dankook University, Cheonan, Korea.
Dankook University · KRDankook University Hospital · KR

Funding

Ministry of Science and TechnologyNational Research Foundation of Korea 2017R1D1A1B03033219
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe gap prepulse inhibition of the acoustic startle response has been used to screen tinnitus in an animal model. Here, we examined changes in the auditory late response under various conditions of gap prepulse inhibition. SUBJECTS AND

methodsWe recruited 19 healthy adults (5 males, 14 females) and their auditory late responses were recorded after various stimuli with or without gap prepulsing. The N1 and P2 responses were selected for analysis. The gap prepulse inhibition was estimated to determine the optimal auditory late response in the gap prepulse paradigm.

resultsWe found that the gap per se generated a response that was very similar to the response elicited by sound stimuli. This critically affected the gap associated with the maximal inhibition of the stimulus response. Among the various gap-stimulus intervals (GSIs) between the gap and principal stimulus, the GSI of 150 ms maximally inhibited the response. However, after zero padding was used to minimize artifacts after a P2 response to a gap stimulus, the differences among the GSIs disappeared.

conclusionsOverall, the data suggest that both the prepulse inhibition and the gap per se should be considered when using the gap prepulse paradigm to assess tinnitus in humans.

Indexed as

Auditory evoked responsesPrepulse inhibitionTinnitus

Identifiers

PMID32397012
PMCPMC7364191
OpenAlexW3024487607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.