Evidence map›Paper›PMID 32396845›Full record

ReviewTrends in endocrinology and metabolism: TEM2020

Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment.

Luke R Lemmerman, Devleena Das, Natalia Higuita-Castro, Raghavendra G Mirmira, Daniel Gallego-Perez

Open access · greenAbstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  7. Diabetology and Nanotechnology: A Compelling Combination.Recent patents on nanotechnology · 2025
    Review
  8. Review
  9. Article
  10. Advances in Nanomedicine for Precision Insulin Delivery.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Nanomedicine in the Treatment of Diabetes.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luke R LemmermanThe Ohio State University, Department of Biomedical Engineering, Columbus, OH 43210, USA.
Devleena DasThe Ohio State University, Department of Biomedical Engineering, Columbus, OH 43210, USA.
Natalia Higuita-CastroThe Ohio State University, Department of Biomedical Engineering, Columbus, OH 43210, USA; The Ohio State University, Department of Surgery, Columbus, OH 43210, USA.
Raghavendra G MirmiraThe University of Chicago, Kovler Diabetes Center and the Department of Medicine, Chicago, IL 60637, USA.
Daniel Gallego-PerezThe Ohio State University, Department of Biomedical Engineering, Columbus, OH 43210, USA; The Ohio State University, Department of Surgery, Columbus, OH 43210, USA. Electronic address: gallegoperez.1@osu.edu.
The Ohio State University · USUniversity of Chicago · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI GRAEME I BELL · 2013 to 2026
$20.9M
Transcriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5M
Validation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5M
Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and ReplicationR01DK124906 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2020 to 2026
$4.0M
Novel nanoscale approaches to whole tissue reprogrammingDP2EB028110 · NIBIB · OHIO STATE UNIVERSITY · PI GALLEGO-PEREZ, DANIEL · 2018 to 2022
$2.7M
NIBIB NIH HHS DP2 EB028110NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK105588NIDDK NIH HHS R01 DK124906
6 · The paper itself

Abstract

Traditional methods for diabetes management require constant and tedious glucose monitoring (GM) and insulin injections, impacting quality of life. The global diabetic population is expected to increase to 439 million, with approximately US$490 billion in healthcare expenditures by 2030, imposing a significant burden on healthcare systems worldwide. Recent advances in nanotechnology have emerged as promising alternative strategies for the management of diabetes. For example, implantable nanosensors are being developed for continuous GM, new nanoparticle (NP)-based imaging approaches that quantify subtle changes in β cell mass can facilitate early diagnosis, and nanotechnology-based insulin delivery methods are being explored as novel therapies. Here, we provide a holistic summary of this rapidly advancing field compiling all aspects pertaining to the management of diabetes.

Indexed as

Cell- and Tissue-Based TherapyMonitoring, PhysiologicNanogelsTransdermal PatchDiabetes MellitusHumansInsulinNanomedicineInsulinNanogelscarbon nanotubescell therapiesdiabetesmagnetic nanoparticlesnanogelsnanotechnologyquantum dotsscaffolds

Identifiers

PMID32396845
PMCPMC7987328
OpenAlexW3010248114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.