Evidence map›Paper›PMID 32396709›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Exploring Ovarian Cancer Cell Resistance to Rhenium Anticancer Complexes.

Sierra C Marker, A Paden King, Robert V Swanda, Brett Vaughn, Eszter Boros, Shu-Bing Qian, Justin J Wilson

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sierra C MarkerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
A Paden KingDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Robert V SwandaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Brett VaughnDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA.
Eszter BorosDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA.ORCID 0000-0002-4186-6586
Shu-Bing QianDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.ORCID 0000-0002-4127-1136
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID 0000-0002-4086-7982

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
O-GlcNAc Signaling in Translational Control of Stress ResponseR01GM122814 · NIGMS · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2017 to 2020
$1.3M
Dynamic mRNA m6A modification in oncogenic translationR21CA227917 · NCI · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2018 to 2019
$371k
NCI NIH HHS R21 CA227917NIGMS NIH HHS R01 GM122814NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

Rhenium tricarbonyl complexes have been recently investigated as novel anticancer agents. However, little is understood about their mechanisms of action, as well as the means by which cancer cells respond to chronic exposure to these compounds. To gain a deeper mechanistic insight into these rhenium anticancer agents, we developed and characterized an ovarian cancer cell line that is resistant to a previously studied compound [Re(CO)

Indexed as

Antineoplastic AgentsATP Binding Cassette Transporter, Subfamily BCell Line, TumorCoordination ComplexesDrug Resistance, NeoplasmFemaleGene Expression ProfilingHumansMetallothioneinNF-E2-Related Factor 2Ovarian NeoplasmsRheniumVerapamilAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BCoordination ComplexesMetallothioneinMT1E protein, humanNFE2L2 protein, humanNF-E2-Related Factor 2RheniumVerapamilbioinorganic chemistrycancerdrug resistancegene expressionrhenium

Identifiers

PMID32396709
PMCPMC7482417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.