Evidence map›Paper›PMID 32396498›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction.

Alexander L Pendleton, Andrew T Antolic, Amy C Kelly, Melissa A Davis, Leticia E Camacho, Kevin Doubleday, Miranda J Anderson, Paul R Langlais, Ronald M Lynch, Sean W Limesand

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 36 citations in OpenAlex.

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  6. Slow-twitch oxidative myofiber proportions and capillary number per myofiber are reduced in growth-restricted fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
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  20. A yeast-based system to study SARS-CoV-2 MbioRxiv : the preprint server for biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexander L PendletonPhysiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.ORCID 0000-0003-2290-9074
Andrew T AntolicSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Amy C KellySchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Melissa A DavisSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Leticia E CamachoSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Kevin DoubledayDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, Arizona.
Miranda J AndersonSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Paul R LanglaisPhysiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.
Ronald M LynchPhysiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.
Sean W LimesandPhysiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.ORCID 0000-0002-5851-0439
University of Arizona · US

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Prevention of Placental Insufficiency Improves Beta-Cells FunctionR01DK084842 · NIDDK · UNIVERSITY OF ARIZONA · PI SEAN W LIMESAND · 2009 to 2026
$5.6M
HHS | National Institutes of Health (NIH) HL007249HHS | National Institutes of Health (NIH) R01DK-084842NHLBI NIH HHS T32 HL007249NIDDK NIH HHS R01 DK084842USDA | National Institute of Food and Agriculture (NIFA) 2015-03545
6 · The paper itself

Abstract

Fetal sheep with placental insufficiency-induced intrauterine growth restriction (IUGR) have lower hindlimb oxygen consumption rates (OCRs), indicating depressed mitochondrial oxidative phosphorylation capacity in their skeletal muscle. We hypothesized that OCRs are lower in skeletal muscle mitochondria from IUGR fetuses, due to reduced electron transport chain (ETC) activity and lower abundances of tricarboxylic acid (TCA) cycle enzymes. IUGR sheep fetuses (

Indexed as

AnimalsCitric Acid CycleDown-RegulationElectron Transport Complex IElectron Transport Complex IIElectron Transport Complex IVFemaleFetal Growth RetardationHamstring MusclesHypoglycemiaHypoxiaIsocitrate DehydrogenaseKetoglutarate Dehydrogenase ComplexMitochondrial ProteinsMitochondria, MuscleMuscle, SkeletalElectron Transport Complex IElectron Transport Complex IIElectron Transport Complex IVIsocitrate DehydrogenaseKetoglutarate Dehydrogenase ComplexMitochondrial ProteinsSuccinate-CoA Ligaseselectron transport chainmitochondriaplacental insufficiencyproteomicstricarboxylic acid cycle

Identifiers

PMID32396498
PMCPMC7468780
OpenAlexW3025550136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.