Evidence map›Paper›PMID 32396371›Full record

ArticleInorganic chemistry2020

Alkyne Functionalization of a Photoactivated Ruthenium Polypyridyl Complex for Click-Enabled Serum Albumin Interaction Studies.

Anja Busemann, Can Araman, Ingrid Flaspohler, Alessandro Pratesi, Xue-Quan Zhou, Vincent H S van Rixel, Maxime A Siegler, Luigi Messori, Sander I van Kasteren, Sylvestre Bonnet

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  5. Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Anja BusemannLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.
Can AramanLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-6961-5607
Ingrid FlaspohlerLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.
Alessandro PratesiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.ORCID http://orcid.org/0000-0002-9553-9943
Xue-Quan ZhouLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.
Vincent H S van RixelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.
Maxime A SieglerSmall Molecule X-ray Facility, Department of Chemistry, John Hopkins University, Baltimore, Maryland 21218, United States.ORCID http://orcid.org/0000-0003-4165-7810
Luigi MessoriLaboratory of Metals in Medicine (MetMed), Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.ORCID http://orcid.org/0000-0002-9490-8014
Sander I van KasterenLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3733-818X
Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-5810-3657
Leiden University · NLUniversity of Florence · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying metal-protein interactions is key for understanding the fate of metallodrugs in biological systems. When a metal complex is not emissive and too weakly bound for mass spectrometry analysis, however, it may become challenging to study such interactions. In this work a synthetic procedure was developed for the alkyne functionalization of a photolabile ruthenium polypyridyl complex, [Ru(tpy)(bpy)(Hmte)](PF

Indexed as

AlkynesAnimalsCattleClick ChemistryCoordination ComplexesCrystallography, X-RayModels, MolecularMolecular ConformationPhotosensitizing AgentsRutheniumSerum Albumin, BovineAlkynesCoordination ComplexesPhotosensitizing AgentsRutheniumSerum Albumin, Bovine

Identifiers

PMID32396371
PMCPMC7268191
OpenAlexW3026024556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.