Evidence map›Paper›PMID 32396237›Full record

ArticleMicrobiology and immunology2020

Identification of the minimum region of Bordetella pertussis Vag8 required for interaction with C1 inhibitor.

Naoki Onoda, Yukihiro Hiramatsu, Shihono Teruya, Koichiro Suzuki, Yasuhiko Horiguchi

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology and immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Naoki OnodaDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Yukihiro HiramatsuDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-6340-864X
Shihono TeruyaDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Koichiro SuzukiDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Yasuhiko HoriguchiDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0002-1592-5861
The University of Osaka · JPKyoto Biken Laboratories (Japan) · JP

Funding

Japan Society for the Promotion of Science 17H04075Japan Society for the Promotion of Science 19K16638
6 · The paper itself

Abstract

An autotransporter of Bordetella pertussis, virulence-associated gene 8 (Vag8), binds and inactivates the complement regulator, C1 inhibitor (C1-Inh), and plays a role in evasion of the complement system. However, the molecular interaction between Vag8 and C1-Inh remains unclear. Here, we localized the minimum region of Vag8 required for interaction with C1-Inh by examining the differently truncated Vag8 derivatives for the ability to bind and inactivate C1-Inh. The truncated Vag8 containing amino-acid residues 102-548, but not 102-479 and 202-648, showed the full activity of intact Vag8, suggesting that the separate 102-202 and 548-648 amino-acid regions of Vag8 mediate the interaction with C1-Inh.

Indexed as

Amino Acid SequenceBacterial ProteinsBordetella pertussisComplement C1 Inhibitor ProteinHost-Pathogen InteractionsHumansImmune EvasionProtein BindingType V Secretion SystemsVirulenceWhooping CoughBacterial ProteinsComplement C1 Inhibitor ProteinSERPING1 protein, humanType V Secretion SystemsBordetella pertussisC1 inhibitorVag8

Identifiers

PMID32396237
PMCPMC7497153
OpenAlexW3024618177

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.