ArticleNucleic acids research2020
GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5' and 3' ends of its target genes.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 93 citations in OpenAlex.
- Insights Into the Role of Lysine Acetylation of Non-Histone Proteins in Plant Immunity.Plant, cell & environment · 2026Review
- Epigenetic-epitranscriptomic crosstalk through TaHAG1-TaNSUN2 coordinates thermotolerance in wheat.Nature communications · 2026Article
- Article
- Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.NPJ Regenerative medicine · 2026Article
- How to improve crop pathogen resistance with epigenetics.Phytopathology research · 2026Review
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- Discovery of variation in genes related to agronomic traits by sequencing the genome of Cucurbita pepo varieties.BMC genomics · 2025Article
- PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure.Nucleic acids research · 2025Article
- CitGATA7 interact with histone acetyltransferase CitHAG28 to promote citric acid degradation by regulating the glutamine synthetase pathway in citrus.Molecular horticulture · 2025Article
- PsDMAP1/PsTIP60-regulated H4K16ac is required for ROS-dependent virulence adaptation ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer.Results and problems in cell differentiation · 2025Review
- Advances in understanding the roles of plant HAT and HDAC in non-histone protein acetylation and deacetylation.Planta · 2024Review
- Mechanism and application of feedback loops formed by mechanotransduction and histone modifications.Genes & diseases · 2024Review
- Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts.Journal of fungi (Basel, Switzerland) · 2024Review
- Genome-wide identification and expression analysis of histone deacetylase and histone acetyltransferase genes in response to drought in poplars.BMC genomics · 2024Article
- ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels.Plant biotechnology journal · 2024Article
- HISTONE DEACETYLASE19 Controls Ovule Number Determination and Transmitting Tract Differentiation.Plant physiology · 2024Article
- Recent advancements in the role of histone acetylation dynamics to improve stress responses in plants.Molecular biology reports · 2024Review
- Review
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Authors and funding
21 authors at 4 institutions in 3 countries.
Funding
Abstract
The modification of histones by acetyl groups has a key role in the regulation of chromatin structure and transcription. The Arabidopsis thaliana histone acetyltransferase GCN5 regulates histone modifications as part of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) transcriptional coactivator complex. GCN5 was previously shown to acetylate lysine 14 of histone 3 (H3K14ac) in the promoter regions of its target genes even though GCN5 binding did not systematically correlate with gene activation. Here, we explored the mechanism through which GCN5 controls transcription. First, we fine-mapped its GCN5 binding sites genome-wide and then used several global methodologies (ATAC-seq, ChIP-seq and RNA-seq) to assess the effect of GCN5 loss-of-function on the expression and epigenetic regulation of its target genes. These analyses provided evidence that GCN5 has a dual role in the regulation of H3K14ac levels in their 5' and 3' ends of its target genes. While the gcn5 mutation led to a genome-wide decrease of H3K14ac in the 5' end of the GCN5 down-regulated targets, it also led to an increase of H3K14ac in the 3' ends of GCN5 up-regulated targets. Furthermore, genome-wide changes in H3K14ac levels in the gcn5 mutant correlated with changes in H3K9ac at both 5' and 3' ends, providing evidence for a molecular link between the depositions of these two histone modifications. To understand the biological relevance of these regulations, we showed that GCN5 participates in the responses to biotic stress by repressing salicylic acid (SA) accumulation and SA-mediated immunity, highlighting the role of this protein in the regulation of the crosstalk between diverse developmental and stress-responsive physiological programs. Hence, our results demonstrate that GCN5, through the modulation of H3K14ac levels on its targets, controls the balance between biotic and abiotic stress responses and is a master regulator of plant-environmental interactions.
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