ArticleJournal of the American Chemical Society2020
Synthesis of Pyrroles through the CuH-Catalyzed Coupling of Enynes and Nitriles.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 87 citations in OpenAlex.
- Building Crosslinking Network via Catalytic Furan-to-Pyrrole Conversion.Angewandte Chemie (International ed. in English) · 2026Article
- Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH-Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Recent Advancements in the Cyclization Strategies of 1,3-Enynes Towards the Synthesis of Heterocyclic/Carbocyclic Frameworks.Chemistry, an Asian journal · 2025Review
- Multimodal Precise Control Over Multiselective Carbonylation of 1,3-Enynes.Journal of the American Chemical Society · 2025Article
- Green Synthesis of Bioactive Pyrrole DerivativesCurrent topics in medicinal chemistry · 2025Review
- Recent Advances in Synthetic Routes to Azacycles.Molecules (Basel, Switzerland) · 2023Review
- Direct synthesis of pentasubstituted pyrroles and hexasubstituted pyrrolines from propargyl sulfonylamides and allenamides.Chemical science · 2021Article
- Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines.Journal of the American Chemical Society · 2021Article
- Radical-based functionalization-oriented construction: rapid assembly of azaarene-substituted highly functionalized pyrroles.Chemical science · 2021Article
- Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives.Beilstein journal of organic chemistry · 2021Review
- Copper-catalyzed functionalization of enynes.Chemical science · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents and a broad range of functional groups, providing a variety of N-H pyrroles in good yields and with high regioselectivity. We propose that the Cu-based catalyst promotes both the initial reductive coupling and subsequent cyclization steps. Density functional theory (DFT) calculations were performed to elucidate the reaction mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.