Evidence map›Paper›PMID 32395893›Full record

ArticleJournal of veterinary internal medicine2020

Cardiovascular-renal axis disorder and acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy.

Mengmeng Liu, Liza S Köster, Geoffrey T Fosgate, Christopher C Chadwick, Íñigo Sanz-González, Peter David Eckersall, Paul R Wotton, Anne T French

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Feline comorbidities: cardiovascular and kidney diseases.Journal of feline medicine and surgery · 2026
    Review
  3. Article
  4. Evidence for chronic inflammation in cats with cardiomyopathies.Journal of feline medicine and surgery · 2025
    Article
  5. Article
  6. Article
  7. LRG1: an emerging player in disease pathogenesis.Journal of biomedical science · 2022
    Review
  8. The Feline Cardiomyopathies: 1. General concepts.Journal of feline medicine and surgery · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Mengmeng LiuDepartment of Small Animal Clinical Sciences, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-8944-3016
Liza S KösterDepartment of Small Animal Clinical Sciences, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Geoffrey T FosgateFaculty of Veterinary Science, Department of Production Animal Studies, University of Pretoria, Onderstepoort, South Africa.
Christopher C ChadwickLife Diagnostics Inc., West Chester, Pennsylvania, USA.
Íñigo Sanz-GonzálezDepartment of Small Animal Clinical Sciences, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Peter David EckersallInstitute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
Paul R WottonDepartment of Small Animal Clinical Sciences, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Anne T FrenchDepartment of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, St Kitts and Nevis.
University of Glasgow · GBOnderstepoort Veterinary Academic Hospital · ZARoss University School of Veterinary Medicine · KNUniversity of Tennessee at Knoxville · USWest Chester University · US

Funding

University of Glasgow Veterinary Fund Small Grant Scheme
6 · The paper itself

Abstract

backgroundCurrently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood.

objectiveTo identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular-renal axis disorder and systemic inflammatory response. ANIMALS: Twenty-five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls.

methodsCase control and observational case series. The following serum biomarkers were compared among the 3 cat groups: a cardiorenal profile that included N-terminal pro-brain natriuretic peptide (NT-proBNP), symmetric dimethylarginine (SDMA), and creatinine and an inflammatory profile that included 7 acute-phase proteins (APPs). Survival analyses and longitudinal studies were performed in CHF cats.

resultsAll cardiorenal biomarkers were positively correlated and higher in CHF cats, and high NT-proBNP and SDMA were associated with poor clinical outcome. Cats with CHF had significantly higher leucine-rich alpha-2-glycoprotein 1, serum amyloid A, and ceruloplasmin, and these APPs were positively correlated with NT-proBNP and left atrial size. In a multivariable survival analysis, alpha-1-acid glycoprotein concentration (P = .01), body weight (P = .02) and left atrial-to-aortic root ratio (P = .01) were independent prognostic factors for CHF in these cats. CONCLUSIONS AND CLINICAL IMPORTANCE: In cats, CHF is an inflammatory disorder and outcome in CHF may be determined by the extent of inflammation and possibly the amount of residual renal function. These novel biomarkers have potential use for the clinical management, prognosis, and future research into CHF and cardiomyopathy in cats.

Indexed as

Acute-Phase ProteinsAnimalsArginineBiomarkersCardiomyopathiesCase-Control StudiesCat DiseasesCatsCreatinineFemaleHeart FailureInflammationKidney DiseasesMaleNatriuretic Peptide, BrainPeptide FragmentsAcute-Phase ProteinsArginineBiomarkersCreatinineNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)symmetric dimethylarginineacute-phase proteinAGPbiomarkercardiorenal syndromeceruloplasminfeline cardiomyopathyLRG1NT-proBNPSAASDMA

Identifiers

PMID32395893
PMCPMC7255652
OpenAlexW3025637381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.