Evidence map›Paper›PMID 32395885›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2020

Carotid Plaque Strain Indices Were Correlated With Cognitive Performance in a Cohort With Advanced Atherosclerosis, and Traditional Doppler Measures Showed no Association.

Carol C Mitchell, Stephanie M Wilbrand, Thomas D Cook, Nirvedh H Meshram, Catherine N Steffel, Rebecca Nye, Tomy Varghese, Bruce P Hermann, Robert J Dempsey

Abstract read
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In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Lagrangian deformation tracking for strain imaging.Progress in biomedical engineering (Bristol, England) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carol C MitchellDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-6445-3306
Stephanie M WilbrandDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Thomas D CookDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Nirvedh H MeshramDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-4005-9798
Catherine N SteffelDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Rebecca NyeDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Tomy VargheseDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-3299-9130
Bruce P HermannDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Robert J DempseyDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
In-vivo Quantitative Ultrasound Imaging of Carotid Plaque Validated with 3D Reconstructed Histopathology SectionsF31HL141008 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI STEFFEL, CATHERINE NICOLE · 2018 to 2019
$64k
National Heart, Lung, and Blood Institute of the National Institutes of Health Award Number F31 HL 141008National Institutes of Health, under Ruth L. Kirschstein National Research Service Award, from the National Heart Lung and Blood Institute to the University of Wisconsin-Madison Cardiovascular Research Center T32 HL-007936NHLBI NIH HHS F31 HL141008NHLBI NIH HHS T32 HL007936NIH HHS Grant R01 NS064034NINDS NIH HHS R01 NS064034Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin-Madison with funding from the Wisconsin Alumni Research FoundationSupport for carotid strain imaging research was also provided by the Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin-Madison with funding from the Wisconsin Alumni Research FoundationWe are grateful to Siemens Medical Solutions USA, Inc., for providing the S2000 Axius Direct Ultrasound Research Interface (URI) and software licenses.We gratefully acknowledge the support of NVIDIA Corporation with the donation of the Tesla K40 GPU used for carotid strain imaging.Wisconsin Alumni Research Foundation
6 · The paper itself

Abstract

objectivesTraditional Doppler measures have been used to predict cognitive performance in patients with carotid atherosclerosis. Novel measures, such as carotid plaque strain indices (CPSIs), have shown associations with cognitive performance. We hypothesized that lower mean middle cerebral artery (MCA) velocities, higher bulb-internal carotid artery (ICA) velocities, the MCA pulsatility index (PI), and CPSIs would be associated with poorer cognitive performance in individuals with advanced atherosclerosis.

methodsNeurocognitive testing, carotid ultrasound imaging, transcranial Doppler imaging, and carotid strain imaging were performed on 40 patients scheduled for carotid endarterectomy. Kendall tau correlations were used to examine relationships between cognitive tests and the surgical-side maximum peak systolic velocity (PSV; from the bulb, proximal, mid, or distal ICA), mean MCA velocity and PI, and maximum CPSIs (axial, lateral, and shear strain indices used to characterize plaque deformations with arterial pulsation). Cognitive measures included age-adjusted indices of verbal fluency, verbal and visual learning/memory, psychomotor speed, auditory attention/working memory, visuospatial construction, and mental flexibility.

resultsParticipants had a median age of 71.0 (interquartile range, 9.75) years; 26 were male (65%), and 14 were female (35%). Traditional Doppler parameters, PSV, mean MCA velocity, and MCA PI did not predict cognitive performance (all P > .05). Maximum CPSIs were significantly associated with cognitive performance (P < .05).

conclusionsTraditional velocity measurements of the maximum bulb-ICA PSV, mean MCA velocity, and PI were not associated with cognitive performance in patients with advanced atherosclerotic disease; however, maximum CPSIs were associated with cognitive performance. These findings suggest that cognition may be associated with unstable plaque rather than blood flow.

Indexed as

AtherosclerosisCarotid StenosisBlood Flow VelocityCarotid ArteriesChildCognitionFemaleHumansMaleMiddle Cerebral ArteryUltrasonography, Doppler, Transcranialcarotid artery diseasecerebrovascular diseasevascular imaging/diagnostics

Identifiers

PMID32395885
PMCPMC7531894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.