ArticleThe Journal of antimicrobial chemotherapy2020
Plasmids of novel incompatibility group IncpRBL16 from Pseudomonas species.
Article in The Journal of antimicrobial chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 31 citations in OpenAlex.
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- Characterization and Implications of IncP-2A Plasmid pMAS152 Harboring Multidrug Resistance Genes in Extensively Drug-ResistantMicroorganisms · 2024Article
- Conjugative Plasmid pPPUT-Tik1-1 from a PermafrostInternational journal of molecular sciences · 2023Article
- Abundant diversity of accessory genetic elements and associated antimicrobial resistance genes in pseudomonas aeruginosa isolates from a single Chinese hospital.Annals of clinical microbiology and antimicrobials · 2023Article
- Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and DiverseMicrobiology spectrum · 2023Article
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- The defense island repertoire of the Escherichia coli pan-genome.PLoS genetics · 2023Article
- Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin CarryingMicrobiology spectrum · 2022Article
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- Emerging and re-emerging KPC-producing hypervirulentEmerging microbes & infections · 2022Article
- Precise classification of antimicrobial resistance-associated IncP-2 megaplasmids for molecular epidemiological studies on Pseudomonas species.The Journal of antimicrobial chemotherapy · 2022Article
- Characterization of a Conjugative Multidrug Resistance IncP-2 Megaplasmid, pPAG5, from a Clinical Pseudomonas aeruginosa Isolate.Microbiology spectrum · 2022Article
- Comparative analysis reveals the modular functional structure of conjugative megaplasmid pTTS12 ofFrontiers in microbiology · 2022Article
- Diversification and prevalence of the quinolone resistanceVirulence · 2021Article
- An IncP-2 plasmid sublineage associated with dissemination ofEmerging microbes & infections · 2021Article
- Epidemic Territorial Spread of IncP-2-Type VIM-2 Carbapenemase-Encoding Megaplasmids in Nosocomial Pseudomonas aeruginosa Populations.Antimicrobial agents and chemotherapy · 2021Article
- Novel Chromosome-Borne Accessory Genetic Elements Carrying Multiple Antibiotic Resistance Genes inFrontiers in cellular and infection microbiology · 2021Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo dissect genomic features of IncpRBL16 plasmids from Pseudomonas.
methodsAn extensive genomic comparison was applied to all 17 available sequenced IncpRBL16 plasmids, including 8 sequenced in this study and another 2 sequenced in two of our previous studies.
resultsConserved IncpRBL16 backbone markers repAIncpRBL16 together with its iterons, parB2-parA, che, pil and ter were present in all 17 plasmids. At least 18 regions or sites across IncpRBL16 genomes exhibited major modular differences, including insertion of accessory modules, deletion of backbone regions surrounding insertion sites and substitution of multiple-gene backbone regions. Ten plasmids carried a sole IncpRBL16 replicon, while exogenous acquisition of an auxiliary replicon (located in an accessory module) besides the primary IncpRBL16 replicon was observed in each of the remaining seven plasmids. The 17 IncpRBL16 plasmids carried at least 71 different accessory modules, notably including Tn1403-related regions, Tn7-family transposons, Tn6571-family transposons, integrative and conjugative elements, and integrative and mobilizable elements. There were a total of 40 known resistance genes, which were involved in resistance to 15 categories of antibiotics and heavy metals, notably including blaIMP-9, blaIMP-45, blaVIM-2, blaDIM-2, blaOXA-246, blaPER-1, aphA and armA.
conclusionsDifferent IncpRBL16 plasmids contain different profiles of accessory modules and thus diverse collections of resistance genes. To the best of our knowledge, this is the first report of fully sequenced blaOXA-246-carrying (p12939-PER) and blaPER-1-carrying (p12939-PER and pA681-IMP) IncpRBL16 plasmids and also that of 14 novel (first identified in this study) and additionally 31 newly named (first designated in this study, but with previously determined sequences) mobile elements.
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