Evidence map›Paper›PMID 32395649›Full record

ArticleHeliyon2020

The severity of internal carotid artery stenosis is associated with the circulating Th17 level.

A Yu Filatova, A V Potekhina, E A Pylaeva, A K Osokina, N Yu Ruleva, O A Pogorelova, M I Tripoten, E A Noeva, T V Balakhonova, V P Masenko and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

A Yu FilatovaLaboratory of Cell Immunology of Institute of Experimental Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
A V PotekhinaDepartment of Pulmonary Hypertension and Heart Diseases of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
E A PylaevaLaboratory of Cell Immunology of Institute of Experimental Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
A K OsokinaDepartment of Pulmonary Hypertension and Heart Diseases of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
N Yu RulevaLaboratory of Cell Immunology of Institute of Experimental Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
O A PogorelovaDepartment of Ultrasound Research Methods of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
M I TripotenDepartment of Ultrasound Research Methods of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
E A NoevaDepartment of Pulmonary Hypertension and Heart Diseases of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
T V BalakhonovaDepartment of Ultrasound Research Methods of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
V P MasenkoDepartment of Neurohumoral Regulation of Cardiovascular Diseases of Institute of Clinical Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
T I ArefievaLaboratory of Cell Immunology of Institute of Experimental Cardiology of FSBO, National Medical Research Center of Cardiology of Russian Ministry of Health, Russia.
National Medical Research Center of Cardiology · RUInstitute of Experimental Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimImmune and inflammatory reactions contribute to the progression of atherosclerosis. The walls of the different arteries and segments of the arteries have heterogeneous haemodynamic and histological features. We aimed to explore the relationship between the circulating T-cell subsets and the abundance of carotid atherosclerosis in different segments of carotid arteries.

methods70 patients underwent ultrasound duplex scanning to determine the degree of stenosis of the common carotid artery (CCA), the CCA bifurcation or the internal carotid artery (ICA). The blood frequencies of T-, B-, NK-cells, regulatory T cells (Treg), activated T-helpers (Th), IL10-producing Th, Th1 and Th17, as well as blood levels of hsCRP, sCD25, IL10 and IL17a were assessed.

resultsThe frequencies of Th17 were increased in patients with ICA stenosis >35% and >50% vs. patients with ICA stenosis <35%. Th17 blood level ≥0.55 % of lymphocytes was associated with more severe stenosis of ICA (OR 4.3 (1.0-17.6), p < 0.05 for ICA stenosis of 35-50% and 6.8 (1.3-35.0), p < 0.05 for ICA stenosis >50%). BMI positively correlated with the CCA bifurcation stenosis degree (r = 0.33, p < 0.05).

conclusionThe severity of ICA stenosis can be associated with the circulating Th17 level.

Indexed as

AtherosclerosisCardiologyCarotid arteriesCell biologyDiagnosticsImmunologyInflammationT-helpers 17Ultrasound

Identifiers

PMID32395649
PMCPMC7210401
OpenAlexW3021869046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.