Evidence map›Paper›PMID 32395537›Full record

ArticleAnnals of translational medicine2020

Does the conventional dosage of linezolid necessitate therapeutic drug monitoring?-Experience from a prospective observational study.

Jie Fang, Congqin Chen, Yan Wu, Min Zhang, Ying Zhang, Guochao Shi, Yijin Yao, Hong Chen, Xiaolan Bian

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Jie FangDepartment of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200003, China.
Congqin ChenDepartment of Pharmacy, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian 361000, China.
Yan WuDepartment of Pharmacy, Chinese and Western Medicine Hospital of Kun Shan, Suzhou 215300, China.
Min ZhangDepartment of Pharmacy Services, Boston Medical Center, Boston, MA, USA.
Ying ZhangDepartment of Pharmacy, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou 215000, China.
Guochao ShiDepartment of Respiration and Critical Care Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200003, China.
Yijin YaoDepartment of Respiration and Critical Care Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200003, China.
Hong ChenDepartment of Respiration and Critical Care Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200003, China.
Xiaolan BianDepartment of Pharmacy, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200003, China.
Shanghai Jiao Tong University · CNRuijin Hospital · CNBoston Medical Center · USSuzhou University of Science and Technology · CNTraditional Chinese Medicine Hospital of Kunshan · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objectives of the present prospective observational study conducted in patients receiving conventional dosage of linezolid was to define the pharmacodynamic range of linezolid exposure, to assess the inter-individual variability in linezolid concentrations, and to define if therapeutic drug monitoring (TDM) of linezolid may be necessary for Chinese population.

methodsPatients included in this study underwent linezolid TDM trough concentration (

resultsA total of 84 patients who had 153 linezolid

conclusionsOur results suggest that the pharmacodynamic range of linezolid

Indexed as

Linezolidoverexposurerenal functiontherapeutic drug monitoring (TDM)underexposure

Identifiers

PMID32395537
PMCPMC7210126
OpenAlexW3015719116

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.