Evidence map›Paper›PMID 32395389›Full record

ArticleJournal of periodontal & implant science2020

Evaluation of tissue ingrowth and reaction of a porous polyethylene block as an onlay bone graft in rabbit posterior mandible.

Teerapan Sosakul, Pongsatorn Tuchpramuk, Waraporn Suvannapruk, Autcharaporn Srion, Bunyong Rungroungdouyboon, Jintamai Suwanprateeb

Open access · hybridAbstract read
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In one paragraph

Article in Journal of periodontal & implant science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Teerapan SosakulDepartment of Prosthodontics, Khon Kaen University Faculty of Dentistry, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0002-6339-2043
Pongsatorn TuchpramukOffice of Academic Affairs, Mahasarakham University Faculty of Veterinary Sciences, Maha Sarakham, Thailand.ORCID https://orcid.org/0000-0001-6899-5946
Waraporn SuvannaprukBiofunctional Materials and Devices Research Group, National Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency, Pathumthani, Thailand.ORCID https://orcid.org/0000-0001-9138-9418
Autcharaporn SrionBiofunctional Materials and Devices Research Group, National Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency, Pathumthani, Thailand.ORCID https://orcid.org/0000-0003-3133-8752
Bunyong RungroungdouyboonDepartment of Mechanical Engineering, Thammasat University Faculty of Engineering, Pathumthani, Thailand.ORCID https://orcid.org/0000-0002-2475-5825
Jintamai SuwanprateebBiofunctional Materials and Devices Research Group, National Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency, Pathumthani, Thailand.ORCID https://orcid.org/0000-0002-5555-3927
National Science and Technology Development Agency · THKhon Kaen University · THMahasarakham University · THThammasat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA new form of porous polyethylene, characterized by higher porosity and pore interconnectivity, was developed for use as a tissue-integrated implant. This study evaluated the effectiveness of porous polyethylene blocks used as an onlay bone graft in rabbit mandible in terms of tissue reaction, bone ingrowth, fibrovascularization, and graft-bone interfacial integrity.

methodsTwelve New Zealand white rabbits were randomized into 3 treatment groups according to the study period (4, 12, or 24 weeks). Cylindrical specimens measuring 5 mm in diameter and 4.5 mm in thickness were placed directly on the body of the mandible without bone bed decortication, fixed in place with a titanium screw, and covered with a collagen membrane. Histologic and histomorphometric analyses were done using hematoxylin and eosin-stained bone slices. Interfacial shear strength was tested to quantify graft-bone interfacial integrity.

resultsThe porous polyethylene graft was observed to integrate with the mandibular bone and exhibited tissue-bridge connections. At all postoperative time points, it was noted that the host tissues had grown deep into the pores of the porous polyethylene in the direction from the interface to the center of the graft. Both fibrovascular tissue and bone were found within the pores, but most bone ingrowth was observed at the graft-mandibular bone interface. Bone ingrowth depth and interfacial shear strength were in the range of 2.76-3.89 mm and 1.11-1.43 MPa, respectively. No significant differences among post-implantation time points were found for tissue ingrowth percentage and interfacial shear strength (

conclusionsWithin the limits of the study, the present study revealed that the new porous polyethylene did not provoke any adverse systemic reactions. The material promoted fibrovascularization and displayed osteoconductive and osteogenic properties within and outside the contact interface. Stable interfacial integration between the graft and bone also took place.

Indexed as

Bone-implant InterfaceBone regenerationHistologyInterfacial shear strengthPolyethylenesRabbit

Identifiers

PMID32395389
PMCPMC7192824
OpenAlexW3012851889

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.