Evidence map›Paper›PMID 32395168›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2020

Fundus Autofluorescence in Maternally Inherited Diabetes and Deafness: The Gold Standard for Monitoring Maculopathy?

Christopher A Ovens, Kate Ahmad, Clare L Fraser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Clinical insights into mitochondrial retinopathy: A case report on m.3243A>G mutation and macular dystrophy.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher A OvensDiscipline of Ophthalmology and Eye Health, the Sydney Medical School, the Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Kate AhmadDepartment of Neurology, Royal North Shore Hospital, St Leonards, Australia.
Clare L FraserSave Sight Institute, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia.ORCID 0000-0002-0379-7743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disease associated with dysfunction of the retinal pigment epithelium and photoreceptor outer segments in a peri-foveal arrangement. If chorioretinal atrophy develops, patients risk losing vision. We retrospectively analysed three patients with genetically proven MIDD, assessing atrophy size and progression using overlay in photoshop. Patients showed increase in chorioretinal atrophy of 205%, 46% and 34%, respectively. We also found location-specific progression, where hyper-autofluorescent deposits evolved into areas of atrophy. These results support the use of fundus autofluorescence as a valuable tool in monitoring disease progression and providing prognostic information for clinicians and patients.

Indexed as

Atrophyfundus autofluorescencemaculopathyMIDD

Identifiers

PMID32395168
PMCPMC7202421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.